In the study single-cell RNA sequencing technology was used to obtain an unbiased global view of the role of TRα1 in hypothalamus development, cell-type diversity and the cellular transcriptome. The groups of Prof. Malte Spielmann and Prof. Jens Mittag could show that defective TRα1 signaling has surprisingly little effect on the development of hypothalamic neuronal populations. In contrast, it heavily affects the development of hypothalamic oligodendrocytes, which seem to require TRα1 signaling for full maturation. They subsequently demonstrate that early postnatal thyroid hormone action is crucial for the development of this cell type. Read more. 
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