TH transporters at brain barriers
Prof. Dr. Heike Heuer & Prof. Dr. med. Markus Schwaninger
Characterising the cell-specific function of the TH transporters Mct8 and Oatp1c1 at murine brain barriers will disclose the pathways by which TH reaches defined neural target cells. This information is mandatory for understanding and eventually manipulating local changes in TH action in CNS under (patho-) physiological conditions. By taking advantage of Mct8/Oatp1c1 DKO mice as an animal model for human MCT8 deficiency, we further aim to develop a MCT8 gene therapy approach targeting murine brain barriers in order to restore proper TH action in the CNS.
Project Team Members
| Name | Position | Phone | |
|---|---|---|---|
| Dr. rer. nat. Boyka Markova | Postdoc (Team Heuer) | +49 201 723 5677 | |
| Androniki Alevyzaki | PhD candidate (Team Heuer) | +49 201 723 5677 | |
| Adriana Arrulo Pereira | PhD candidate (Team Schwaninger) | +49 451 3101 7220 |
Further Information
Selected Publications
Thyroid hormone transporters.
Groeneweg S, van Geest FS, Peeters RP, Heuer H, Visser WE.
2020. Endocrine Reviews 41(2). doi: 10.1210/endrev/bnz008
Impaired endothelium-mediated cerebrovascular reactivity promotes anxiety and respiration disorders in mice.
Wenzel J, Hansen CE, Bettoni C, Vogt MA, Lembrich B, Natsagdorj R, Huber G, Brands J, Schmidt K, Assmann JC, Stölting I, Saar K, Sedlacik J, Fiehler J, Ludewig P, Wegmann M, Feller N, Richter M, Müller-Fielitz H, Walther T, König GM, Kostenis E, Raasch W, Hübner N, Gass P, Offermanns S, de Wit C, Wagner CA, and Schwaninger M.
2020. Proc Natl Acad Sci U S A 117: 1753-1761. doi: 10.1073/pnas.1907467117
Hippocampal neurogenesis requires cell-autonomous thyroid hormone signaling.
Mayerl S, Heuer H, Ffrench-Constant C.
2020. Stem Cell Reports 14: 845-860. doi: 10.1016/j.stemcr.2020.03.014
Thyroid hormone transporters Mct8 and Oatp1c1 control skeletal muscle regeneration.
Mayerl S, Schmidt M, Doycheva D, Darras VM, Hüttner SS, Boelen A, Visser TJ, Kaether C, Heuer H*, von Maltzahn J*. *equal contribution.
2018. Stem Cell Reports 10: 1959-1974; doi: 10.1016/j.stemcr.2018.03.021
Tanycytes control the hormonal output of the hypothalamic-pituitary-thyroid axis.
Müller-Fielitz H, Stahr M, Bernau M, Richter M, Abele S, Krajka V, Benzin A, Wenzel J, Kalies K, Mittag J, Heuer H, Offermanns S, Schwaninger M.
2017. Nature Comm 8: 481 doi: 10.1038/s41467-017-00604-6
Gene therapy decreases seizures in a model of Incontinentia pigmenti.
Dogbevia GK, Töllner K, Körbelin J, Bröer S, Ridder DA, Grasshoff H, Brandt C, Wenzel J, Straub BK, Trepel M, Löscher W, Schwaninger M.
2017. Ann Neurol 82: 93-104. doi: 10.1002/ana.24981
A brain microvasculature endothelial cell-specific viral vector with the potential to treat neurovascular and neurological diseases.
Körbelin J, Dogbevia G, Michelfelder S, Ridder DA, Hunger A, Wenzel J, Seismann H, Lampe M, Bannach J, Pasparakis M, Kleinschmidt JA, Schwaninger M*, Trepel M*. *equal contribution.
2016. EMBO Mol Med. 8:609-25. doi: 10.15252/emmm.201506078
Transporters MCT8 and OATP1C1 maintain murine brain thyroid hormone homeostasis.
Mayerl S, Müller J, Bauer R, Richert S, Kassmann CM, Darras VM, Buder K, Boelen A, Visser TJ, and Heuer H.
2014. J Clin Invest. 124: 1987-1999. doi: 10.1172/JCI70324
In vitro and mouse studies support therapeutic utility of triiodothyroacetic acid in MCT8 deficiency.
Kersseboom S, Horn S, Visser WE, Chen J, Friesema ECH, Vaurs-Barrière C, Peeters RP, Heuer H*, Visser TJ*. *equal contribution.
2014. Molecular Endocrinology 28: 1961-1970. doi: 10.1210/me.2014-1135
TAK1 in brain endothelial cells mediates fever and lethargy.
Ridder DA, Lang MF, Salinin S, Röderer JP, Struss M, Maser-Gluth C, Schwaninger M.
2011. J Exp Med 208: 2615-2623. doi: 10.1084/jem.20110398
