Collaborative Research Centre / Transregio 296
Local Control of Thyroid Hormone Action (LOCOTACT)
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Project P01
TH transporters at brain barriers
Prof. Dr. Heike Heuer
&
Prof. Dr. med. Markus Schwaninger
Project P02
Impact of TH on tanycyte functions and the relevance on central regulation of the liver and hormone uptake
Dr. Helge Müller-Fielitz
Project P03 (E)
Transporter expression and TH action in the brain
Prof. Dr. med. Ingo Bechmann & Prof. Dr. Heike Biebermann
Project P04
TH action in hiPSC-derived brain organoids
Prof. Dr. med. Peter Kühnen
&
Prof. Dr. rer. nat. Robert Opitz
Project P05
Novel pharmacotherapies for the treatment of central TH deprivation associated with Mct8/Oatp1c1 deficiency
Prof. Dr. Paul T. Pfluger
&
PD Dr. Timo D. Müller
Project P06 (E)
THRA deficiency and Allan-Herndon-Dudley-Syndrome: Defects of local TH function during human brain development
Prof. Dr. med. Heiko Krude & Prof. Dr. med. Markus Schülke-Gerstenfeld
Project P07
A brain imaging approach to TH function in consequence to mutations in TH receptors and transporter proteins
PD Dr. med. Anna Cirkel (née Göbel)
Project P08
Local TH transport and action in ischaemic brain injury
Dr. Friederike Langhauser
,
Prof. Dr. med. PhD Dagmar Führer
&
Prof. Dr. med. Christoph Kleinschnitz
Project P09
TH transporters in myelin formation and regeneration
Prof. Dr. Heike Heuer
&
Prof. Dr. Daniel R. Engel
Project P10
Local TH action in acute and chronic ischaemic heart disease
Prof. Dr. med. PhD Dagmar Führer
,
Prof. Dr. med. Lars C. Möller
&
Prof. Dr. Kristina Lorenz
Project P11
Role of the enigmatic TRα2 isoform in regulating cardiac TH function
Prof. Dr. Frank Kaiser
Project P12
TH receptor α1 at the crossroad of autonomic and cardiac functions in mice
Prof. Dr. Jens Mittag
Project P13
TH receptor-clock interaction in NAFLD development
Prof. Dr. Henrik Oster
Project P14
Control of cellular TH metabolism in human and mouse NASH
Prof. Dr. Jens Mittag
Project P15
Liver-specific TH activity in NAFLD and NASH
Prof. Dr. med. Knut Mai
&
Prof. Dr. med. Frank Tacke
Project P16 (E)
Strategies to increase local T3 availability in liver
Prof. Dr. Josef Köhrle, Dr. Eva K. Wirth
Project P17
Control of deiodinase type 1 (DIO1) expression and its protective function in human hepatocytes
Prof. Dr. Lutz Schomburg
Project P18
Hepatic TH signalling in acute and acute-on-chronic liver injury
Prof. Dr. med. Lars C. Möller
,
Prof. Dr. med. Christian M. Lange
&
PD Dr. Denise Zwanziger
Project P19
Impact of TH transport on seizure generation
Dr. Steffen Mayerl
Research Area Z01
Establishment and provision of human pluripotent stem cell (hiPSC)-derived 2D and 3D cellular models of brain, liver and heart and technologies for their analysis
Dr. Harald Stachelscheid
Research Area Z02
Integrated Research Training Group (iRTG)
Prof. Dr. rer. nat. Heike Heuer
,
Dr. rer. hum. biol. Helge Müller-Fielitz
&
Dr. rer. nat. Robert Opitz
Research Area Z03
Research Data Management (INF)
Dr. Stephanie Rehwald
&
Prof. Dr. med. PhD Dagmar Führer