Collaborative Research Centre / Transregio 296

Local Control of Thyroid Hormone Action (LOCOTACT)

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Projects

Project P01

TH transporters at brain barriers

Prof. Dr. Heike Heuer & Prof. Dr. med. Markus Schwaninger

Project P02

Impact of TH on tanycyte functions and the relevance on central regulation of the liver and hormone uptake

Dr. Helge Müller-Fielitz

Project P03

Transporter expression and TH action in the brain

Prof. Dr. med. Ingo Bechmann & Prof. Dr. Heike Biebermann

Project P04

TH action in hiPSC-derived brain organoids

Prof. Dr. med. Peter Kühnen

Project P05

Novel pharmacotherapies for the treatment of central TH deprivation associated with Mct8/Oatp1c1 deficiency

Prof. Dr. Paul T. Pfluger  &  PD Dr. Timo D. Müller

Project P06

THRA deficiency and Allan-Herndon-Dudley-Syndrome: Defects of local TH function during human brain development

Prof. Dr. med. Heiko Krude  &  Prof. Dr. med. Markus Schülke-Gerstenfeld

Project P07

A brain imaging approach to TH function in consequence to mutations in TH receptors and transporter proteins

PD Dr. med. Anna Cirkel (née Göbel)  &  Prof. Dr. med. Thomas F. Münte

Project P08

Local TH transport and action in ischaemic brain injury

Dr. Friederike Langhauser,  Prof. Dr. med. PhD Dagmar Führer &  Prof. Dr. med. Christoph Kleinschnitz

Project P09

TH transporters in myelin formation and regeneration

Prof. Dr. Heike Heuer &  Prof. Dr. Daniel R. Engel

Project P10

Local TH action in acute and chronic ischaemic heart disease

Prof. Dr. med. PhD Dagmar Führer,  Prof. Dr. med. Lars C. Möller  &  Prof. Dr. Kristina Lorenz

Project P11

Role of the enigmatic TRα2 isoform in regulating cardiac TH function

Prof. Dr. Frank Kaiser

Project P12

TH receptor α1 at the crossroad of autonomic and cardiac functions in mice

Prof. Dr. Jens Mittag

Project P13

TH receptor-clock interaction in NAFLD development

Prof. Dr. Henrik Oster

Project P14

Control of cellular TH metabolism in human and mouse NASH

Prof. Dr. Henriette Kirchner  &  Prof. Dr. Jens Mittag

Project P15

Liver-specific TH activity in NAFLD and NASH

Prof. Dr. med. Joachim Spranger,  Prof. Dr. med. Frank Tacke  &  Dr. Eva K. Wirth

Project P16

Strategies to increase local T3 availability in liver

Prof. Dr. Josef Köhrle,  Dr. Eva K. Wirth

Project P17

Control of deiodinase type 1 (DIO1) expression and its protective function in human hepatocytes

Prof. Dr. Lutz Schomburg

Project P18

Hepatic TH signalling in acute and acute-on-chronic liver injury

Prof. Dr. med. Lars C. Möller, Prof. Dr. med. Christian M. Lange & PD Dr. Denise Zwanziger

Project P19

Impact of TH transport on seizure generation

Dr. Steffen Mayerl

Research Area Z01

Establishment and provision of human pluripotent stem cell (hiPSC)-derived 2D and 3D cellular models of brain, liver and heart and technologies for their analysis

Dr. Harald Stachelscheid

Research Area Z02

Integrated Research Training Group (iRTG)

Prof. Dr. rer. nat. Heike Heuer, Dr. rer. hum. biol. Helge Müller-Fielitz & Prof. Dr. med. Peter Kühnen

Research Area Z03

Research Data Management (INF)

Dr. Stephanie Rehwald  &  Prof. Dr. med. PhD Dagmar Führer

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Central Office

Administration

University of Duisburg-Essen
c/o University Hospital Essen
Department of Endocrinology, Diabetes and Metabolism
Phone: +49 201/723 - 5350
E-Mail: locotact@uk-essen.de

CRC/TR296

As a truly interdisciplinary research consortium LocoTact is well equipped to meet the challenge of defining local control of TH action and to develop translational strategies tailored to cells and tissues with the perspective to capitalise on the power of the hormone to treat rare or prevalent diseases.

Speaker at UDE

Prof. Dr. Dr. Dagmar Führer-Sakel
Dagmar.Fuehrer-Sakel@uk-essen.de

Co-Speaker at UzL

Prof. Dr. Jens Mittag
jens.mittag@uni-luebeck.de

Co-Speaker at Charité

Prof. Dr. Heiko Krude
heiko.krude@charite.de

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