Projects

TH transporters at brain barriers

Prof. Dr. Heike Heuer & Prof. Dr. med. Markus Schwaninger

Impact of TH on tanycyte functions and the relevance on central regulation of the liver and hormone uptake

Dr. Helge Müller-Fielitz

Transporter expression and TH action in the brain

Prof. Dr. med. Ingo Bechmann & Prof. Dr. Heike Biebermann

TH action in hiPSC-derived brain organoids

Prof. Dr. med. Peter Kühnen & Prof. Dr. rer. nat. Robert Opitz

Novel pharmacotherapies for the treatment of central TH deprivation associated with Mct8/Oatp1c1 deficiency

Prof. Dr. Paul T. Pfluger  &  PD Dr. Timo D. Müller

THRA deficiency and Allan-Herndon-Dudley-Syndrome: Defects of local TH function during human brain development

Prof. Dr. med. Heiko Krude  &  Prof. Dr. med. Markus Schülke-Gerstenfeld

A brain imaging approach to TH function in consequence to mutations in TH receptors and transporter proteins

PD Dr. med. Anna Cirkel (née Göbel) 

Local TH transport and action in ischaemic brain injury

Dr. Friederike Langhauser,  Prof. Dr. med. PhD Dagmar Führer &  Prof. Dr. med. Christoph Kleinschnitz

TH transporters in myelin formation and regeneration

Prof. Dr. Heike Heuer &  Prof. Dr. Daniel R. Engel

Local TH action in acute and chronic ischaemic heart disease

Prof. Dr. med. PhD Dagmar Führer,  Prof. Dr. med. Lars C. Möller  &  Prof. Dr. Kristina Lorenz

Role of the enigmatic TRα2 isoform in regulating cardiac TH function

Prof. Dr. Frank Kaiser

TH receptor α1 at the crossroad of autonomic and cardiac functions in mice

Prof. Dr. Jens Mittag

TH receptor-clock interaction in NAFLD development

Prof. Dr. Henrik Oster

Control of cellular TH metabolism in human and mouse NASH

Prof. Dr. Jens Mittag

Liver-specific TH activity in NAFLD and NASH

Prof. Dr. med. Knut Mai & Prof. Dr. med. Frank Tacke 

Strategies to increase local T3 availability in liver

Prof. Dr. Josef Köhrle,  Dr. Eva K. Wirth

Control of deiodinase type 1 (DIO1) expression and its protective function in human hepatocytes

Prof. Dr. Lutz Schomburg

Hepatic TH signalling in acute and acute-on-chronic liver injury

Prof. Dr. med. Lars C. Möller, Prof. Dr. med. Christian M. Lange & PD Dr. Denise Zwanziger

Impact of TH transport on seizure generation

Dr. Steffen Mayerl

Establishment and provision of human pluripotent stem cell (hiPSC)-derived 2D and 3D cellular models of brain, liver and heart and technologies for their analysis

Dr. Harald Stachelscheid

Integrated Research Training Group (iRTG)

Prof. Dr. rer. nat. Heike Heuer, Dr. rer. hum. biol. Helge Müller-Fielitz & Dr. rer. nat. Robert Opitz

Research Data Management (INF)

Dr. Stephanie Rehwald  &  Prof. Dr. med. PhD Dagmar Führer