Collaborative Research Centre / Transregio 296

Local Control of Thyroid Hormone Action (LOCOTACT)

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Published: 03 March 2023

Inspiring and motivating insights into diverse career options

The LOCOTACT Career Days were a successful event for all participants and guest speakers! We look back on two days of great insights into the many career opportunities available to our Clinician Scientists, PostDocs, and MDs and PhDs.

Many thanks go to: Dagmar Führer, Alexander Boreham, Kostja Renko, Timo Müller, Marius Richter, Christian Strasburger, Denise Zwanziger, Peter Kühnen, Corina Madreiter-Sokolowski, Roman Rehor, Vedrana Tabor, Niels-Peter Becker, Mariel Morales-Sahm, Thomas Wallach & Bettina Otto.

For more details, please have a look on our programme.

Published: 13 February 2023

LOCOTACT publication deciphers new role of thyroid hormones in early brain development!

In the study single-cell RNA sequencing technology was used to obtain an unbiased global view of the role of TRα1 in hypothalamus development, cell-type diversity and the cellular transcriptome. The groups of Prof. Malte Spielmann and Prof. Jens Mittag could show that defective TRα1 signaling has surprisingly little effect on the development of hypothalamic neuronal populations. In contrast, it heavily affects the development of hypothalamic oligodendrocytes, which seem to require TRα1 signaling for full maturation. They subsequently demonstrate that early postnatal thyroid hormone action is crucial for the development of this cell type. Read more. 
Find the publication here.

Published: 09 February 2023

Successful start of the Joint Online Event Series: Equity and Female Opportunities in Academia

On Wednesday, 08.02.2023 we started into our online event series with a workshop entitled: Are you hiring the best people? Limiting unconscious bias by structuring employee selection held by Prof. Dr. Tanja Hentschel, University of Amsterdam, Amsterdam Business School.

Tanja Hentschel explained why and how biases and stereotypes in the application process can influence personnel selection.
All participants got great insights how we can reduce these biases through professional personnel selection processes and how we can customize them.
Because in the end, we all want to hire the person who is best suited for the position and not the person who is most like us, don’t we?

Many thanks to Tanja Hentschel and all participants from TRR 289 Treatment Expectation and CRC/TR 296 LOCOTACT!

 

Please find the upcoming events in the Joint Online Event Series here.

Published: 17 October 2022

FAZ - Health Podcast: The thyroid - small organ with great impact

Our LOCOTACT speaker Prof. Dagmar Führer-Sakel (Clinic for Endocrinology, Diabetology and Metabolism, University Hospital Essen) was invited to the Frankfurter Allgemeine Zeitung (FAZ) health podcast.
Under the title "The thyroid - small organ with  great impact" she talks about the task of this fascinating gland, how it works - and what T4 and T3 are all about.
Listen to the German Podcast episode here: Podcast FAZ
Der Poster Award
Published: 04 October 2022

Poster Award at NeuroRNA Conference

The virtual NeuroRNA Conference 2022 - RNA regulation in brain function and disease, was organized to discuss the advances in research at the interface between RNA biology and neuroscience. We congratulate Robert Opitz who's poster presentation has been awarded with a poster prize.
The NeuroRNA Conference took place from 28.-30. September 2022. Look here for further information.
Congratulations to Robert and his team!
ETA Logo
Published: 26 September 2022

ETA Project Research Grant for LOCOTACT PostDoc Sebastian Hönes

The LOCOTACT consortium congratulates our PostDoc Sebastian Hönes (P18) for receiving this year's ETA Project Research Grant (Basic). With this grant Sebastian receives 20.000 € for his research. 
On behalf of all LOCOTACT members, we wish you every success with the project!
Published: 22 September 2022

LOCOTACT Event - Panel Discussion on the movie Picture a Scientist

The fact that discrimination against female scientists is certainly not an outdated problem, but a highly relevant topic, could be experienced by all participants of the panel discussion on September 22. Inspired by the content of the film Picture A Scientist and moderated by Dr. Christina Altstötter-Gleich, the panel guests Prof. Britta Siegmund, Prof. Nicole Krämer, Prof. Karen Shire and Prof. Dagmar Führer-Sakel discussed their impressions of the film, their own experiences in their professional careers and everyday work, as well as cultural and structural differences between Germany, Europe and North America. The panel guests were in agreement that it is important to be a good example, to strengthen and support young female colleagues and, above all, to advocate for equal treatment in decision-making committees.
LOCOTACT would like to thank all panelists for the great contributions and inspirations that were shared with the audience, as well as the openness to talk about very personal experiences and looks back on a successful evening. Thank you!

Published: 10 September 2022

44th Annual Meeting of the European Thyroid Association

During the last four days many of our LOCOTACT researchers traveled to Brussels to participate in the 44th Annual Meeting of the European Thyroid Association!
 
We are proud that many of our members have been invited to give talks and present posters: 
Oral presentations: Dagmar Führer-Sakel (P08, P10, Z03; Essen), Lars Möller (P10, P18; Essen), Josef Köhrle (P16; Berlin), Steffen Mayerl (P19; Essen), Pieter Vancamp (Z03; Essen), Leonardo de Assis (P13; Lübeck), Nina Härting (P11; Essen), Robert Opitz (P06; Berlin)
Poster presentations: Valeria Fernandez-Vallone (Z01; Berlin), Androniki Alevyzaki (P01; Essen), Andrea Alcaide Martín (P19; Essen), Adina Graffunder (P04; Berlin), Nuria López Alcántara (P14; Lübeck), Audrey Bresser (P04; Berlin), Julia Maier (P12; Lübeck), Sabrina Asaad (P17; Berlin)
news eta meeting collage min
Furthermore, several prizes have been awarded to LOCOTACT researchers:
ETA Travel Grant: Nina Härting (group of Frank Kaiser, Essen)
ETA Poster Awards: Andrea Alcaide Martín (group of Steffen Mayerl, Essen), Audrey Bresser (group of Peter Kühnen/Robert Opitz, Berlin)
ETA Lissitzky Career Award: Prof. Josef Köhrle (Berlin). This prestigious prize is awarded every second year to a distinguished member of the Association who has made a life-long and outstanding contribution to thyroid research!
news eta meeting collage 2 min
Congratulations to all winners and many thanks to everyone
who contributed to ETA and represented LOCOTACT!!!
​
Published: 20 August 2022

LOCOTACT Lectures - Mathew Fuxjager

The LOCOTACT consortium thanks Prof. Dr. Mathew Fuxjager, Associate Professor at the Department of Ecology, Evolution, and Organismal Biology at Brown University, Rode Island, for his fascinating lecture on hormones in birds and the effect on skeletal muscle and behaviour  
 
The lively discussion after the talk reflected the broad interest and fascination among the listeners, who are mostly used to hear about endokrine-related topics in human research.
Thank you Matt, for encouraging to thinking out of the box! 

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Upcoming Events

07
Jun
Save the Date - LOCOTACT Retreat 2023 and International Conference
Atlantic Congress Hotel
-
Essen

30
Mar
LOCOTACT Lectures - Ana Guadaño-Ferraz
Online (Zoom)

see all events

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Central Office

Administration

University of Duisburg-Essen
c/o University Hospital Essen
Department of Endocrinology, Diabetes and Metabolism
Phone: +49 201/723 - 5350
E-Mail: locotact@uk-essen.de

CRC/TR296

As a truly interdisciplinary research consortium LocoTact is well equipped to meet the challenge of defining local control of TH action and to develop translational strategies tailored to cells and tissues with the perspective to capitalise on the power of the hormone to treat rare or prevalent diseases.

Speaker at UDE

Prof. Dr. Dr. Dagmar Führer-Sakel
Dagmar.Fuehrer-Sakel@uk-essen.de

Co-Speaker at UzL

Prof. Dr. Jens Mittag
jens.mittag@uni-luebeck.de

Co-Speaker at Charité

Prof. Dr. Heiko Krude
heiko.krude@charite.de

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