2023
Regulation of thyroid hormone gatekeepers by TSH in tanycytes.
Chandrasekar A, …, Schwaninger M, Müller-Fielitz H
2023. Thyroid (accepted)
3,3′,5-tri-iodothyroacetic acid (TRIAC) transporters.
Chen Z, Yildiz S, Markova B,.., Heuer H, Meima M, Visser WE
2023. Thyroid (in revision)
Thyroid hormone receptor α controls regulatory T cell differentiation and function.
Wenzek C, Siemes D, Hönes GS, Pastille E, Härting N, Kaiser F, Moeller LC, Engel DR, Westendorf AM, Führer D
2023. (submitted)
Generation of THRB-GS(E125G_G126S) and THRB-KO human iPSC lines to study noncanonical thyroid hormone signaling.
Ludwik KA, Jahn R, Schörding AK, Moeller LC, Stachelscheid H
2023. (in press) doi: 10.1016/j.scr.2023.103275
Cardiac recovery from pressure overload is not altered by thyroid hormone status in old mice.
Kerp H, Gassen J, Grund SC, Hönes GS, Dörr S, Mittag J, Härting N, Kaiser F, Moeller LC, Lorenz K, Führer D
2023. bioRxiv. doi: 10.1101/2023.11.16.567497
Spatiotemporal expression of thyroid hormone transporter MCT8 and THRA mRNA in human cerebral organoids recapitulating first trimester cortex development.
Graffunder A, Bresser AAJ, Fernandez-Vallone V, Megges M, Stachelscheid H, Kuehnen P, Opitz R
2023. bioRxiv. doi: 0.1101/2023.11.16.567497
Canonical and noncanonical contribution of thyroid hormone receptor isoforms alpha and beta to cardiac hypertrophy and heart rate in male mice.
Geist D, Hönes GS, Grund SC, Pape J, Siemes D, Spangenberg P, Tolstik E, Dörr S,…,. Mittag J, Engel DR, Führer D, Lorenz K, Moeller LC
2023. bioRxiv. doi: 10.1101/2023.11.24.568041
Comparative phenotyping of mice reveals canonical and noncanonical physiological functions of TRα and TRβ.
Hönes GS, Geist D, Wenzek C, Pfluger PT, Müller TD, …, de Angelis M, Führer D, Moeller LC
2023. bioRxiv. doi: 10.1101/2023.11.26.568063
Post-ischemic triiodothyronine treatment improves stroke outcome by stabilizing the blood-brain barrier.
Ullrich D, Fuehrer-Sakel D, Heuer H, Mayerl S, …, Kleinschnitz C, Langhauser F
2023. bioRxiv. doi: 10.1101/2023.11.21.568025
Hepatobiliary long-term consequences of COVID-19: dramatically increased rate of secondary sclerosing cholangitis in critically ill COVID-19 patients.
Leonhardt S, Jürgensen C, Frohme J, Grajecki D, Adler A, Sigal M, Leonhardt J, Voll JM, Kruse JM, Körner R, Eckardt KU, Janssen HJ, Gebhardt V, Schmittner MD; Pa-COVID-19 collaborative study group; Frey C, Müller-Ide H, Bauer M, Thibeault C, Kurth F, Sander LE, Müller T, Tacke F
2023. Hepatol Int. Dec;17(6):1610-1625. doi: 10.1007/s12072-023-10521-0.
Generation of iPSC lines with SLC16A2:G401R or SLC16A2 knock out.
Ludwik KA, Opitz R, Jyrch S, Megges M, Weiner J, Beule D, Kühnen P, Stachelscheid H
2023. Stem Cell Res. Nov 21;73:103256. doi: 10.1016/j.scr.2023.103256
Changes in brain structure in subjects with resistance to thyroid hormone due to THRB mutations.
Rogge B, Heldmann M, Chatterjee K, Moran C, Göttlich M, Uter J, Wagner-Altendorf TA, Steinhardt J, Brabant G, Münte TF, Cirkel A
2023. Thyroid Res. Nov 6;16(1):34. doi: 10.1186/s13044-023-00176-2
Characteristics of specialists treating hypothyroid patients: the "THESIS" collaborative.
Žarković M, Attanasio R, Nagy EV, Negro R, Papini E, Perros P, Cohen CA, Akarsu E, Alevizaki M, Ayvaz G, Bednarczuk T, Berta E, Bodor M, Borissova AM, Boyanov M, Buffet C, Burlacu MC, Ćirić J, Díez JJ, Dobnig H, Fadeyev V, Field BCT, Fliers E, Frølich JS, Führer D, Galofré JC, Hakala T, Jiskra J, Kopp P, Krebs M, Kršek M, Kužma M, Lantz M, Lazúrová I, Leenhardt L, Luchytskiy V, McGowan A, Melo M, Metso S, Moran C, Morgunova T, Mykola T, Beleslin BN, Niculescu DA, Perić B, Planck T, Poiana C, Puga FM, Robenshtok E, Rosselet P, Ruchala M, Riis KR, Shepelkevich A, Unuane D, Vardarli I, Visser WE, Vrionidou A, Younes YR, Yurenya E, Hegedüs L
2023. Front Endocrinol (Lausanne). Nov 7;14:1225202. doi: 10.3389/fendo.2023.1225202
Establishing Patient-Centered Outcomes for MCT8 Deficiency: Stakeholder Engagement and Systematic Literature Review.
Wilpert NM, Tonduti D, Vaia Y, Krude H, Sarret C, Schuelke M
2023. Neuropsychiatr Dis Treat. Oct 20;19:2195-2216. doi: 10.2147/NDT.S379703
Partial resistance to thyroid hormone-induced tachycardia and cardiac hypertrophy in mice lacking thyroid hormone receptor β.
Dore R, Sentis SC, Johann K, Lopez-Alcantara N, Resch J, Moeller LC, Führer D, Obermayer B, Opitz R, Mittag J
2023. bioRxiv. doi: 10.1101/2023.11.21.567193
Tuning of liver circadian transcriptome rhythms by thyroid hormone state in male mice.
de Assis LVM,…, Mittag J, Oster H
2023. bioRxiv. doi: 10.1101/2023.09.23.559037
Serum Selenium-Binding Protein 1 (SELENBP1) in Burn Injury: A Potential Biomarker of Disease Severity and Clinical Course.
Turan TL, Klein HJ, Hackler J, Hoerner L, Rijntjes E, Graf TR, Plock JA, Schomburg L
2023. Antioxidants (Basel). Oct 29;12(11):1927. doi: 10.3390/antiox12111927
Selenoprotein P deficiency is associated with higher risk of incident heart failure.
Jujic A, Molvin J, Schomburg L, Hartmann O, Bergmann A, Melander O, Magnusson M
2023. Free Radic Biol Med. Oct;207:11-16. doi: 10.1016/j.freeradbiomed.2023.07.007
Selenium status and its determinants in very old adults: insights from the Newcastle 85+ Study.
Perri G, Mathers JC, Martin-Ruiz C, Parker C, Walsh JS, Eastell R, Demircan K, Chillon TS, Schomburg L, Robinson L, Hill TR
2023 Br J Nutr. Oct 25:1-10. doi: 10.1017/S0007114523002398
Hepatic inflammatory responses in liver fibrosis.
Hammerich L, Tacke F
2023. Nat Rev Gastroenterol Hepatol. Oct;20(10):633-646. doi: 10.1038/s41575-023-00807-x
Maternal thyroid hormone receptor β activation in mice sparks brown fat thermogenesis in the offspring.
Oelkrug R, Harder L, Pedaran M, Hoffmann A, Kolms B, Inderhees J, Gachkar S, Resch J, Johann K, Jöhren O, Krause K, Mittag J
2023. Nat Commun. Oct 24;14(1):6742. doi: 10.1038/s41467-023-42425-w
Thyroid hormone receptor alpha modulates fibrogenesis in hepatic stellate cells.
Manka P, Coombes JD, Sydor S, Swiderska-Syn MK, Best J, Gauthier K, van Grunsven LA, Oo YH, Wang C, Diehl AM, Hönes GS, Moeller LC, Figge A, Boosman RJ, Faber KN, Tannapfel A, Goetze O, Aspichueta P, Lange CM, Canbay A, Syn WK
2023. Liver Int. Oct 23. doi: 10.1111/liv.15759.
Proteome Analysis of Thyroid Hormone Transporter Mct8/Oatp1c1-Deficient Mice Reveals Novel Dysregulated Target Molecules Involved in Locomotor Function.
Siemes D*, Vancamp P*, Markova B, Spangenberg P, Shevchuk O, Siebels B, Schlüter H, Mayerl S#, Heuer H#, Engel DR#
2023. Cells. Oct 19;12(20):2487. doi: 10.3390/cells12202487 *,# equal contribution.
Thyroid Studies Collaboration. The optimal healthy ranges of thyroid function defined by the risk of cardiovascular disease and mortality: systematic review and individual participant data meta-analysis.
Xu Y, Derakhshan A, Hysaj O, Wildisen L, Ittermann T, Pingitore A, Abolhassani N, Medici M, Kiemeney LALM, Riksen NP, Dullaart RPF, Trompet S, Dörr M, Brown SJ, Schmidt B, Führer-Sakel D, Vanderpump MPJ, Muendlein A, Drexel H, Fink HA, Ikram MK, Kavousi M, Rhee CM, Bensenor IM, Azizi F, Hankey GJ, Iacoviello M, Imaizumi M, Ceresini G, Ferrucci L, Sgarbi JA, Bauer DC, Wareham N, Boelaert K, Bakker SJL, Jukema JW, Vaes B, Iervasi G, Yeap BB, Westendorp RGJ, Korevaar TIM, Völzke H, Razvi S, Gussekloo J, Walsh JP, Cappola AR, Rodondi N, Peeters RP, Chaker L
2023. Lancet Diabetes Endocrinol. Oct;11(10):743-754. doi: 10.1016/S2213-8587(23)00227-9
Cardiac multiscale bioimaging: from nano- through micro- to mesoscales.
Tolstik E, Lehnart SE, Soeller C, Lorenz K, Sacconi L
2023. Trends Biotechnol. Oct 6:S0167-7799(23)00241-X. doi: 10.1016/j.tibtech.2023.08.007
Long-COVID cognitive impairments and reproductive hormone deficits in men may stem from GnRH neuronal death.
Sauve F, Nampoothiri S, Clarke SA, Fernandois D, Ferreira Coêlho CF, Dewisme J, Mills EG, Ternier G, Cotellessa L, Iglesias-Garcia C, Mueller-Fielitz H, Lebouvier T, Perbet R, Florent V, Baroncini M, Sharif A, Ereño-Orbea J, Mercado-Gómez M, Palazon A, Mattot V, Pasquier F, Catteau-Jonard S, Martinez-Chantar M, Hrabovszky E, Jourdain M, Deplanque D, Morelli A, Guarnieri G, Storme L, Robil C, Trottein F, Nogueiras R, Schwaninger M, Pigny P, Poissy J, Chachlaki K, Maurage CA, Giacobini P, Dhillo W, Rasika S, Prevot V
2023. EBioMedicine. Oct;96:104784. doi: 10.1016/j.ebiom.2023.104784
Thyroid Stimulating Hormone and Thyroid Hormones (Triiodothyronine and Thyroxine): An American Thyroid Association-Commissioned Review of Current Clinical and Laboratory Status.
Van Uytfanghe K, Ehrenkranz J, Halsall D, Hoff K, Loh TP, Spencer CA, Köhrle J
2023. Thyroid. Sep;33(9):1013-1028. doi: 10.1089/thy.2023.0169
Autoantibodies to selenoprotein P in chronic fatigue syndrome suggest selenium transport impairment and acquired resistance to thyroid hormone.
Sun Q, Oltra E, Dijck-Brouwer DAJ, Chillon TS, Seemann P, Asaad S, Demircan K, Espejo-Oltra JA, Sánchez-Fito T, Martín-Martínez E, Minich WB, Muskiet FAJ, Schomburg L
2023. Redox Biol. Sep;65:102796. doi: 10.1016/j.redox.2023.102796
Sex-specific associations of serum selenium and selenoprotein P with type 2 diabetes mellitus and hypertension in the Berlin Aging Study II.
Demircan K, Hybsier S, Chillon TS, Vetter VM, Rijntjes E, Demuth I, Schomburg L
2023. Redox Biol. 2023 Sep;65:102823. doi: 10.1016/j.redox.2023.102823
Matched analysis of circulating selenium with the breast cancer selenotranscriptome: a multicentre prospective study.
Demircan K, Bengtsson Y, Chillon TS, Vallon-Christersson J, Sun Q, Larsson C, Malmberg M, Saal LH, Rydén L, Borg Å, Manjer J, Schomburg L
2023. J Transl Med. Sep 23;21(1):658. doi: 10.1186/s12967-023-04502-y
Lack of thyroid hormone receptor beta is not detrimental for non-alcoholic steatohepatitis progression.
Lopez-Alcantara N, Oelkrug R, Sentis SC, Kirchner H, Mittag J
2023. iScience. Sep 28;26(10):108064. doi: 10.1016/j.isci.2023.108064.
An integrated view of anti-inflammatory and antifibrotic targets for the treatment of NASH.
Tacke F, Puengel T, Loomba R, Friedman SL
2023 J Hepatol. 2023 Aug;79(2):552-566. doi: 10.1016/j.jhep.2023.03.038
Schilddrüsenerkrankungen bei Frauen und Männern – Status quo und neuer Forschungsbedarf [Diseases of the thyroid gland in men and women-Status quo and new research needs].
Lampropoulou E, Brandenburg T, Führer D
2023. Inn Med (Heidelb). Aug;64(8):758-765. German. doi: 10.1007/s00108-023-01553-7
GIP receptor agonism improves dyslipidemia and atherosclerosis independently of body weight loss in preclinical mouse model for cardio-metabolic disease.
Sachs S, Götz A, Finan B, Feuchtinger A, DiMarchi RD, Döring Y, Weber C, Tschöp MH, Müller TD, Hofmann SM
2023. Cardiovasc Diabetol. Aug 17;22(1):217. doi: 10.1186/s12933-023-01940-2
Local Thyroid Hormone Action in Brain Development.
Alcaide Martin A, Mayerl S
2023 Int J Mol Sci. 2023 Aug 2;24(15):12352. doi: 10.3390/ijms241512352.
The Microenvironment of the Pathogenesis of Cardiac Hypertrophy.
Bazgir F, Nau J, Nakhaei-Rad S, Amin E, Wolf MJ, Saucerman JJ, Lorenz K, Ahmadian MR
2023. Cells. Jul 4;12(13):1780. doi: 10.3390/cells12131780
Non-alcoholic steatohepatitis disrupts diurnal liver transcriptome rhythms in mice.
de Assis LVM, Demir M, Oster H.
2023. Cell Mol Gastroenterol Hepatol. Jun 16(3):341-354 doi: 10.1016/j.jcmgh.2023.05.008.
Thyroid hormone transporter Mct8/Oatp1c1 deficiency compromises proper oligodendrocyte maturation in the mouse CNS.
Mayerl S, Heuer H.
2023. Neurobiol Dis. Jun 10:106195. doi: 10.1016/j.nbd.2023.106195.
Resistance to thyroid hormone induced tachycardia in RTHα syndrome.
Dore R, Watson L, Hollidge S, Krause C, Sentis SC, Oelkrug R, Geißler C, Johann K, Pedaran M, Lyons G, Lopez-Alcantara N, Resch J, Sayk F, Iwen KA, Franke A, Boysen TJ, Dalley JW, Lorenz K, Moran C, Rennie KL, Arner A, Kirchner H, Chatterjee K, Mittag J.
2023. Nat Commun. Jun 7;14(1):3312. doi: 10.1038/s41467-023-38960-1
ASSURED-optimized CRISPR protocol for knockout/SNP knockin in hiPSCs.
Ludwik KA, Telugu N, Schommer S, Stachelscheid H, Diecke S.
2023 STAR Protoc. Jul 22;4(3):102406. doi: 10.1016/j.xpro.2023.102406
Hepatic Energy Metabolism under the Local Control of the Thyroid Hormone System.
Seifert J, Chen Y, Schöning W, Mai K, Tacke F, Spranger J, Köhrle J, Wirth EK.
2023. Int J Mol Sci. 24(5):4861. doi: 10.3390/ijms24054861
Fatty Acid Induced Hypermethylation in the Slc2a4 Gene in Visceral Adipose Tissue Is Associated to Insulin-Resistance and Obesity.
Britsemmer JH, Krause C, Taege N, Geißler C, Lopez-Alcantara N, Schmidtke L, Naujack A-M, Wagner J, Wolter S, Mann O, Kirchner H.
2023. Int. J. Mol. Sci. 24(7):6417. doi: org/10.3390/ijms24076417
Comparative analysis of thyroid hormone systems in rodents with subterranean lifestyle.
Gerhardt P, Begall S, Frädrich C, Renko K, Hildebrandt TB, Holtze S, Heinrich A, Sahm A, Meci X, Köhrle J, Rijntjes E, Henning Y.
2023. Sci Rep. 13(1):3122. doi: 10.1038/s41598-023-30179-w
Triac Treatment Prevents Neurodevelopmental and Locomotor Impairments in Thyroid Hormone Transporter Mct8/Oatp1c1 Deficient Mice.
Chen J, Salveridou E, Liebmann L, Sundaram SM, Doycheva D, Markova B, Hübner CA, Boelen A, Visser WE, Heuer H*, Mayerl S*. *equal contribution
2023. Int. J. Mol. Sci. 24(4):3452. doi: 10.3390/ijms24043452
Selenium, Iodine and Iron–Essential Trace Elements for Thyroid Hormone Synthesis and Metabolism.
Köhrle J.
2023. Int. J. Mol. Sci. 24(4):3393. doi: 10.3390/ijms24043393
Evolution of non-thyroidal illness syndrome in acute decompensation of liver cirrhosis and acute-on-chronic liver failure.
Langer MM, Bauschen A, Guckenbiehl S, Klauss S, Lutz T, Denk G, Zwanziger D, Moeller LC and Lange CM.
2023. Front Endocrinol. 14:1104388. doi: 10.3389/fendo.2023.1104388
Single-cell RNA-based phenotyping reveals a pivotal role of thyroid hormone receptor alpha for hypothalamic development.
Sreenivasan VKA, Dore R, Resch J, Maier J, Dietrich C, Henck J, Balachandran S, Mittag J, Spielmann M.
2023. Development. 150 (3): dev201228. doi: 10.1242/dev.201228
Clinical Interpretation of Thyroid Tests: Considerations for Reference Intervals.
Loh TP, Ehrenkranz J, Halsall D, Spencer CA, Van Uytfanghe K, Köhrle J
2023. Thyroid. Apr;33(4):404-406. doi: 10.1089/thy.2023.0096
The role of the circadian clock in the development, progression, and treatment of non-alcoholic fatty liver disease.
de Assis LVM, Demir M, Oster H.
2023. Acta Physiol (Oxf). Mar;237(3):e13915. doi: 10.1111/apha.13915
Antibodies to SARS-CoV-2 in follicular fluids and their association with assisted reproduction.
Chillon TS, Weiss G, Demircan K, Minich WB, Schenk M, Schomburg L
2023. Front Immunol. Mar 17;14:1120328. doi: 10.3389/fimmu.2023.1120328
Rapid and fully automated blood vasculature analysis in 3D light-sheet image volumes of different organs.
Spangenberg P, Hagemann N, Squire A, Förster N, Krauß SD, Qi Y, Mohamud Yusuf A, Wang J, Grüneboom A, Kowitz L, Korste S, Totzeck M, Cibir Z, Tuz AA, Singh V, Siemes D, Struensee L, Engel DR, Ludewig P, Martins Nascentes Melo L, Helfrich I, Chen J, Gunzer M, Hermann DM, Mosig A
2023. Cell Rep Methods. Mar 17;3(3):100436. doi: 10.1016/j.crmeth.2023.100436
Effect of High-Dose Selenium on Postoperative Organ Dysfunction and Mortality in Cardiac Surgery Patients: The SUSTAIN CSX Randomized Clinical Trial.
Stoppe C, McDonald B, Meybohm P, Christopher KB, Fremes S, Whitlock R, Mohammadi S, Kalavrouziotis D, Elke G, Rossaint R, Helmer P, Zacharowski K, Günther U, Parotto M, Niemann B, Böning A, Mazer CD, Jones PM, Ferner M, Lamarche Y, Lamontagne F, Liakopoulos OJ, Cameron M, Müller M, Zarbock A, Wittmann M, Goetzenich A, Kilger E, Schomburg L, Day AG, Heyland DK; SUSTAIN CSX Study Collaborators.
2023. JAMA Surg. Mar 1;158(3):235-244. doi: 10.1001/jamasurg.2022.6855
Thyroid hormones regulate Zfp423 expression in regionally distinct adipose depots through direct and cell-autonomous action.
Roth L, Johann K, Hönes GS, Oelkrug R, Wagner L, Hoffmann A, Krohn K, Moeller LC, Weiner J, Heiker JT, Klöting N, Tönjes A, Stumvoll M, Blüher M, Mittag J, Krause K
2023. Cell Rep. Feb 28;42(2):112088. doi: 10.1016/j.celrep.2023.112088
Translational perspectives from TSHR, MCT8 and TRα research.
Moeller LC
2023 Nat Rev Endocrinol. Feb;19(2):74-75. doi: 10.1038/s41574-022-00785-1
Implications of an HbA1c-based Diabetes Screening on Prevalence and Effect of Dysglycemia in Patients With COVID-19.
Van Baal L, Reinold J, Benson S, Diehl A, Witzke O, Fuehrer D, Tan S
2023. Clin Endocrinol Metab. Feb 15;108(3):697-705. doi: 10.1210/clinem/dgac590
Neuronal Blockade of Thyroid Hormone Signaling Increases Sensitivity to Diet-Induced Obesity in Adult Male Mice.
Rial-Pensado E, Canaple L, Guyot R, Clemmensen C, Wiersema J, Wu S, Richard S, Boelen A, Müller TD, López M, Flamant F, Gauthier K
2023. Endocrinology. Feb 11;164(4):bqad034. doi: 10.1210/endocr/bqad034
2022
Thyroid Hormone Transporters.
Groeneweg S, van Geest FS, Peeters RP, Heuer H, Visser WE
2020. Endocr Rev. Apr 1;41(2):bnz008. doi: 10.1210/endrev/bnz008
Lack of L-type amino acid transporter 2 in murine thyroid tissue induces autophagy.
Venugopalan V, Rehders M, Weber J, Rodermund L, Al-Hashimi A, Bargmann T, Golchert J, Reinecke V, Homuth G, Völker U, Verrey F, Kirstein J, Heuer H, Schweizer U, Braun D, Wirth EK, Brix K
2022. J Mol Endocrinol. Dec 7;70(1):e220060. doi: 10.1530/JME-22-0060
Leptin counteracts hypothermia in hypothyroidism through its pyrexic effects and by stabilizing serum thyroid hormone levels.
Weiner J, Roth L, Kranz M, Brust P, Boelen A, Klöting N, Heiker JT, Blüher M, Tönjes A, Pfluger PT, Stumvoll M, Mittag J, Krause K
2021. Mol Metab. Dec;54:101348. doi: 10.1016/j.molmet.2021.101348
Targeting cardiomyocyte ADAM10 ectodomain shedding promotes survival early after myocardial infarction.
Klapproth E, Witt A, Klose P, Wiedemann J, Vavilthota N, Künzel SR, Kämmerer S, Günscht M, Sprott D, Lesche M, Rost F, Dahl A, Rauch E, Kattner L, Weber S, Mirtschink P, Kopaliani I, Guan K, Lorenz K, Saftig P, Wagner M, El-Armouche A
2022. Nat Commun. Dec 10;13(1):7648. doi: 10.1038/s41467-022-35331-0
Post-COVID-19 Syndrome is Rarely Associated with Damage of the Nervous System: Findings from a Prospective Observational Cohort Study in 171 Patients.
Fleischer M, Szepanowski F, Tovar M, Herchert K, Dinse H, Schweda A, Mausberg AK, Holle-Lee D, Köhrmann M, Stögbauer J, Jokisch D, Jokisch M, Deuschl C, Skoda EM, Teufel M, Stettner M, Kleinschnitz C
2022. Neurol Ther. Dec;11(4):1637-1657. doi: 10.1007/s40120-022-00395-z
Thyroid hormones as a disease modifier and therapeutic target in nonalcoholic steatohepatitis.
Wirth EK, Puengel T, Spranger J, Tacke F.
2022. Expert Rev Endocrinol Metab. 17(5):425-434. doi: 10.1080/17446651.2022.2110864
Deiodinases control local cellular and systemic thyroid hormone availability
Köhrle J, Frädrich C.
2022. Free Radic Biol Med. 193(Pt 1):59-79. doi: 10.1016/j.freeradbiomed.2022.09.024
Cell-Specific Transport and Thyroid Hormone Receptor Isoform Selectivity Account for Hepatocyte-Targeted Thyromimetic Action of MGL-3196
Hönes GS, Sivakumar RG, Hoppe C, König J, Führer D, Moeller LC.
2022. Int J Mol Sci. 23(22):13714. doi: 10.3390/ijms232213714
Validation of Mct8/Oatp1c1 dKO mice as a model organism for the Allan-Herndon-Dudley Syndrome
Maity-Kumar G, Ständer L, DeAngelis M, Lee S, Molenaar A, Becker L, Garrett L, Amerie OV, Hoelter SM, Wurst W, Fuchs H, Feuchtinger A, Gailus-Durner V, Garcia-Caceres C, Othman AE, Brockmann C, Schöffling VI, Beiser K, Krude H, Mroz PA, Hofmann S, Tuckermann J, DiMarchi RD, Hrabe de Angelis M, Tschöp MH, Pfluger PT, Müller TD.
2022. Mol Metab. 66:101616. doi: 10.1016/j.molmet.2022.101616
Cardioprotection by Hypothyroidism Is Not Mediated by Favorable Hemodynamics-Role of Canonical Thyroid Hormone Receptor Alpha Signaling
Pape J, Kerp H, Lieder HR, Geist D, Hönes GS; Moeller LC, Kleinbongard P, Führer D
2022. Int J Mol Sci. 23(21):13340. doi: 10.3390/ijms232113340
TRIAC Treatment Improves Impaired Brain Network Function and White Matter Loss in Thyroid Hormone Transporter Mct8/Oatp1c1 Deficient Mice
Reinwald JR, Weber-Fahr W, Cosa-Linan A, Becker R, Sack M, Falfan-Melgoza C, Gass N, Braun U, Clemm von Hohenberg C, Chen J, Mayerl S, Muente TF, Heuer H*, Sartorius A*. *equal contribution
2022. Int J Mol Sci. 23(24):15547. doi: 10.3390/ijms232415547
Systematic analysis and prediction of genes associated with monogenic disorders on human chromosome X.
Leitão E, Schröder C, Parenti I, Dalle C, Rastetter A, Kühnel T, Kuechler A, Kaya S, Gérard B, Schaefer E, Nava C, Drouot N, Engel C, Piard J, Duban-Bedu B, Villard L, Stegmann APA, Vanhoutte EK, Verdonschot JAJ, Kaiser FJ, Tran Mau-Them F, Scala M, Striano P, Frints SGM, Argilli E, Sherr EH, Elder F, Buratti J, Keren B, Mignot C, Héron D, Mandel JL, Gecz J, Kalscheuer VM, Horsthemke B, Piton A, Depienne C
2022. Nat Commun. Nov 2;13(1):6570. doi: 10.1038/s41467-022-34264-y
Association of COVID-19 mortality with serum selenium, zinc and copper: Six observational studies across Europe.
Demircan K, Chillon TS, Bracken T, Bulgarelli I, Campi I, Du Laing G, Fafi-Kremer S, Fugazzola L, Garcia AA, Heller R, Hughes DJ, Ide L, Klingenberg GJ, Komarnicki P, Krasinski Z, Lescure A, Mallon P, Moghaddam A, Persani L, Petrovic M, Ruchala M, Solis M, Vandekerckhove L, Schomburg L
2022. Front Immunol. Nov 28;13:1022673. doi: 10.3389/fimmu.2022.1022673
Selenoprotein P - Selenium transport protein, enzyme and biomarker of selenium status.
Schomburg L
2022. Free Radic Biol Med. Oct;191:150-163. doi: 10.1016/j.freeradbiomed.2022.08.022
A Questionnaire Survey of German Thyroidologists on the Use of Thyroid Hormones in Hypothyroid and Euthyroid Patients: The THESIS (Treatment of Hypothyroidism in Europe by Specialists: An International Survey) Collaborative.
Vardarli I, Brandenburg T, Hegedüs L, Attanasio R, Nagy E, Papini E, Perros P, Weidemann F, Herrmann K, Führer D
2022. Exp Clin Endocrinol Diabetes. Sep;130(9):577-586. doi: 10.1055/a-1832-0644
Impaired mitochondrial complex IV respiration in peripheral blood mononuclear cells discriminates acute-on-chronic liver failure from acute decompensation.
Langer MM, Eickelmann C, Kleinbongard P, Lange CM
2022. J Hepatol. 2022 Sep;77(3):874-876. doi: 10.1016/j.jhep.2022.04.03
An animal model for Pierpont syndrome: a mouse bearing the Tbl1xr1Y446C/Y446C mutation.
Hu Y, Lauffer P, Stewart M, Codner G, Mayerl S, Heuer H, Ng L, Forrest D, van Trotsenburg P, Jongejan A, Fliers E, Hennekam R, Boelen A
2022. Hum Mol Genet. Aug 25;31(17):2951-2963. doi: 10.1093/hmg/ddac086
How COVID-19 affects microvessels in the brain.
Wenzel J, Schwaninger M
2022. Brain. Jul 29;145(7):2242-2244. doi: 10.1093/brain/awac211
Autoimmunity to selenoprotein P predicts breast cancer recurrence.
Demircan K, Sun Q, Bengtsson Y, Seemann P, Vallon-Christersson J, Malmberg M, Saal LH, Rydén L, Minich WB, Borg Å, Manjer J, Schomburg L
2022. Redox Biol. Jul;53:102346. doi: 10.1016/j.redox.2022.102346
AAV9-MCT8 Delivery at Juvenile Stage Ameliorates Neurological and Behavioral Deficits in a Mouse Model of MCT8-Deficiency.
Liao XH, Avalos P, Shelest O, Ofan R, Shilo M, Bresee C, Likhite S, Vit JP, Heuer H, Kaspar B, Meyer K, Dumitrescu AM, Refetoff S#, Svendsen CN#, Vatine GD#
2022. Thyroid. Jul;32(7):849-859. doi: 10.1089/thy.2022.0034 # equal contribution
3,5-T2-an Endogenous Thyroid Hormone Metabolite as Promising Lead Substance in Anti-Steatotic Drug Development?
Sane R, Wirth EK, Köhrle J.
2022. Metabolites.12(7):582. doi: 10.3390/metabo12070582
Hepatobiliary Thyroid Hormone Deficiency Impacts Bile Acid Hydrophilicity and Aquaporins in Cholestatic C57BL/6J Mice
Kube I, Kowalczyk M, Hofmann U, Ghallab A, Hengstler JG, Führer D, Zwanziger D.
2022. Int. J. Mol. Sci. 23(20), 12355. doi: 10.3390/ijms232012355
Development and validation of an LC-MS/MS methodology for the quantification of thyroid hormones in dko MCT8/OATP1C1 mouse brain
Angelis MD, Maity-Kumar G, Schriever SC, Kozlova EV, Müller TD, Pfluger PT, Curras-Collazo MC, Schramm KW.
2022. J Pharm Biomed Anal 10;221:115038. doi: 10.1016/j.jpba.2022.115038
Gene therapy targeting the blood-brain barrier improves neurological symptoms in a model of genetic MCT8 deficiency
Sundaram SM, Arrulo Pereira A, Müller-Fielitz H, Köpke H, De Angelis M, Müller TD, Heuer H, Körbelin J, Krohn M, Mittag J, Nogueiras R, Prevot V, Schwaninger M.
2022. Brain 5;awac243. doi: 10.1093/brain/awac243
Rewiring of liver diurnal transcriptome rhythms by triiodothyronine (T3) supplementation
de Assis L, Harder L, Lacerda JT, Parsons R, Kaehler M, Cascorbi I, Nagel I, Rawashdeh O, Mittag J, Oster H.
2022. Elife 27;11:e79405 doi: 10.7554/eLife.79405
TRα2-An Untuned Second Fiddle or Fine-Tuning Thyroid Hormone Action?
Hönes S, Härting N, Mittag J, Kaiser F.
2022. Int J Mol Sci 23(13):6998. doi: 10.3390/ijms23136998
Changes in Thyroid Metabolites after Liothyronine Administration: A Secondary Analysis of Two Clinical Trials That Incorporated Pharmacokinetic Data.
Diab N, Desale S, Danielsen M, Köhrle J, Shara N, Jonklaas J
2022. Metabolites. May 24;12(6):476. doi: 10.3390/metabo12060476
Studying Circadian Clock Entrainment by Hormonal Signals.
Pilorz V, Olejniczak I, Oster H
2022. Methods Mol Biol. May 2482:137-152. doi: 10.1007/978-1-0716-2249-0_9
Thromboinflammation in Brain Ischemia: Recent Updates and Future Perspectives.
De Meyer SF, Langhauser F, Haupeltshofer S, Kleinschnitz C, Casas AI
2022. Stroke. May;53(5):1487-1499. doi: 10.1161/STROKEAHA.122.038733
What is the Role of Thyroid Hormone Receptor Alpha 2 (TRα2) in Human Physiology?
Paisdzior S, Schuelke M, Krude H
2022. Exp Clin Endocrinol Diabetes. May;130(5):296-302. doi: 10.1055/a-1716-7980
Too much too soon – Tissue-specific inactivation of deiodinase type 3 prematurely exposes brown fat to thyroid hormone.
Oelkrug R, Mittag J.
2022. Endocrinology bqac032. doi: org/10.1210/endocr/bqac032
The interplay of thyroid hormones and the immune system – where we stand and why we need to know about it.
Wenzek C, Boelen A, Westendorf AM, Engel DR, Möller LC, Führer D
2022. Eur J Endocrinol EJE-21-1171. doi: 10.1530/EJE-21-1171
Distinct actions of the thyroid hormone transporters Mct8 and Oatp1c1 in murine mouse adult hippocampal neurogenesis.
Mayerl S, Alcaide Martin A, Bauer R, Schwaninger M, Heuer H*, ffrench-Constant C*. *equal contribution
2022. Cells 11(3):524. doi: 10.3390/cells11030524
Canonical thyroid hormone receptor β action stimulates hepatocyte proliferation in male mice.
Hönes GS, Kerp H, Hoppe C, Kowalczyk M, Zwanziger D, Baba HA, Führer D, Moeller LC
2022. Endocrinology bqac003. doi: org/10.1210/endocr/bqac003
Thyroid hormone transporter deficiency in mice impacts multiple stages of GABAergic interneuron development.
Mayerl S, Chen J, Salveridou E, Boelen A, Darras VM, Heuer H.
2022. Cerebral Cortex. 32(2):329-341. doi: 10.1093/cercor/bhab211
ACKR3 regulates platelet activation and ischemia-reperfusion tissue injury.
Rohlfing AK, Kolb K, Sigle M, Ziegler M, Bild A, Münzer P, Sudmann J, Dicenta V, Harm T, Manke MC, Geue S, Kremser M, Chatterjee M, Liang C, von Eysmondt H, Dandekar T, Heinzmann D, Günter M, von Ungern-Sternberg S, Büttcher M, Castor T, Mencl S, Langhauser F, Sies K, Ashour D, Beker MC, Lämmerhofer M, Autenrieth SE, Schäffer TE, Laufer S, Szklanna P, Maguire P, Heikenwalder M, Müller KAL, Hermann DM, Kilic E, Stumm R, Ramos G, Kleinschnitz C, Borst O, Langer HF, Rath D, Gawaz M
2022. Nat Commun. Apr 5;13(1):1823. doi: 10.1038/s41467-022-29341-1
Foundations of circadian medicine.
Kramer A, Lange T, Spies C, Finger AM, Berg D, Oster H
2022. PLoS Biol. Mar 24;20(3):e3001567. doi: 10.1371/journal.pbio.3001567
Tentative Application of a Streamlined Protocol to Determine Organ-Specific Regulations of Deiodinase 1 and Dehalogenase Activities as Readouts of the Hypothalamus-Pituitary-Thyroid-Periphery-Axis.
Renko K, Kerp H, Pape J, Rijntjes E, Burgdorf T, Führer D, Köhrle J
2022. Front Toxicol. Mar 21;4:822993. doi: 10.3389/ftox.2022.822993
Cirrhosis-Based Acute-on-Chronic Liver Failure Is Marked by Inflammation and Impaired Liver Regeneration Despite Stat3 Activation.
Lange CM, Al-Juboori K., Rawitzer J, Moellmann D, Schlattjan M, Guckenbiehl S, Willuweit K, Canbay A, Baba HA
2022. Gastro Hep Advances. Mar 1(4):520-530. doi: 10.1016/j.gastha.2022.03.005
Functional Characterization of the Novel and Specific Thyroid Hormone Transporter SLC17A4.
Groeneweg S, van Geest FS, Chen Z, Farina S, van Heerebeek REA, Meima ME, Peeters RP, Heuer H, Medici M, Visser WE
2022. Thyroid. Mar;32(3):326-335. doi: 10.1089/thy.2021.0257
Nuclear Receptors Linking Metabolism, Inflammation, and Fibrosis in Nonalcoholic Fatty Liver Disease.
Puengel T, Liu H, Guillot A, Heymann F, Tacke F, Peiseler M
2022. Int J Mol Sci. 2022 Feb 28;23(5):2668. doi: 10.3390/ijms23052668
Movement disorders in MCT8 deficiency/Allan-Herndon-Dudley Syndrome.
Masnada S, Sarret C, Antonello CE, Fadilah A, Krude H, Mura E, Mordekar S, Nicita F, Olivotto S, Orcesi S, Porta F, Remerand G, Siri B, Wilpert NM, Amir-Yazdani P, Bertini E, Schuelke M, Bernard G, Boespflug-Tanguy O, Tonduti D
2022. Mol Genet Metab. Jan;135(1):109-113. doi: 10.1016/j.ymgme.2021.12.003
Reduced pituitary size in subjects with mutations in the THRB gene and thyroid hormone resistance.
Heldmann M, Chatterjee K, Moran C, Rogge B, Steinhardt J, Wagner-Altendorf T, Göttlich M, Schacht H, Schramm P, Brabant G, Münte TF, Cirkel A
2022. Endocr Connect. Jan 19;11(1):e210473. doi: 10.1530/EC-21-0473
ERK1/2 Activity Is Critical for the Outcome of Ischemic Stroke.
Schanbacher C, Bieber M, Reinders Y, Cherpokova D, Teichert C, Nieswandt B, Sickmann A, Kleinschnitz C, Langhauser F, Lorenz K
2022. Int J Mol Sci. Jan 9;23(2):706. doi: 10.3390/ijms23020706
The Thyroid Hormone Transporter MCT10 Is a Novel Regulator of Trabecular Bone Mass and Bone Turnover in Male Mice.
Lademann F, Mayerl S, Tsourdi E, Verrey F, Leitch VD, Williams GR, Bassett JHD, Hofbauer LC, Heuer H, Rauner M
2022. Endocrinology. Jan 1;163(1):bqab218. doi: 10.1210/endocr/bqab218
2021
The SARS-CoV-2 main protease Mpro causes microvascular brain pathology by cleaving NEMO in brain endothelial cells.
Wenzel J, Lampe J, Müller-Fielitz H, Schuster R, Zille M, Müller K, Krohn M, Körbelin J, Zhang L, Özorhan Ü, Neve V, Wagner JUG, Bojkova D, Shumliakivska M, Jiang Y, Fähnrich A, Ott F, Sencio V, Robil C, Pfefferle S, Sauve F, Coêlho CFF, Franz J, Spiecker F, Lembrich B, Binder S, Feller N, König P, Busch H, Collin L, Villaseñor R, Jöhren O, Altmeppen HC, Pasparakis M, Dimmeler S, Cinatl J, Püschel K, Zelic M, Ofengeim D, Stadelmann C, Trottein F, Nogueiras R, Hilgenfeld R, Glatzel M, Prevot V, Schwaninger M
2021. Nat Neurosci. Nov;24(11):1522-1533. doi: 10.1038/s41593-021-00926-1
Orally Induced Hyperthyroidism Regulates Hypothalamic AMP-Activated Protein Kinase.
Capelli V, Grijota-Martínez C, Dragano NRV, Rial-Pensado E, Fernø J, Nogueiras R, Mittag J, Diéguez C, López M
2021. Nutrients. Nov 24;13(12):4204. doi: 10.3390/nu13124204
Leptin brain entry via a tanycytic LepR-EGFR shuttle controls lipid metabolism and pancreas function.
Duquenne M, Folgueira C, Bourouh C, Millet M, Silva A, Clasadonte J, Imbernon M, Fernandois D, Martinez-Corral I, Kusumakshi S, Caron E, Rasika S, Deliglia E, Jouy N, Oishi A, Mazzone M, Trinquet E, Tavernier J, Kim YB, Ory S, Jockers R, Schwaninger M, Boehm U, Nogueiras R, Annicotte JS, Gasman S, Dam J, Prévot V
2021. Nat Metab. Aug;3(8):1071-1090. doi: 10.1038/s42255-021-00432-5
TSH concentrations in parents and their offspring: a cross-sectional family-based analysis.
Girschik C, Drogge SC, Kowall B, Lehmann N, Stang A, Zwanziger D, Erbel R, Führer D#, Jöckel KH#
2021. Eur J Endocrinol. Nov 26;185(6):855-862. doi: 10.1530/EJE-21-0652 # shared senior authors
Serum selenium, selenoprotein P and glutathione peroxidase 3 as predictors of mortality and recurrence following breast cancer diagnosis: A multicentre cohort study.
Demircan K, Bengtsson Y, Sun Q, Brange A, Vallon-Christersson J, Rijntjes E, Malmberg M, Saal LH, Rydén L, Borg Å, Manjer J, Schomburg L
2021. Redox Biol. Nov;47:102145. doi: 10.1016/j.redox.2021.102145
TRIP6 functions in brain ciliogenesis.
Shukla S, Haenold R, Urbánek P, Frappart L, Monajembashi S, Grigaravicius P, Nagel S, Min WK, Tapias A, Kassel O, Heuer H, Wang ZQ, Ploubidou A, Herrlich P
2021. Nat Commun. Oct 7;12(1):5887. doi: 10.1038/s41467-021-26057-6
Tanycytic networks mediate energy balance by feeding lactate to glucose-insensitive POMC neurons.
Lhomme T, Clasadonte J, Imbernon M, Fernandois D, Sauve F, Caron E, da Silva Lima N, Heras V, Martinez-Corral I, Mueller-Fielitz H, Rasika S, Schwaninger M, Nogueiras R, Prevot V
2021. J Clin Invest. 2021 Sep 15;131(18):e140521. doi: 10.1172/JCI140521
Association between albuminuria and thyroid function in patients with chronic kidney disease.
Reinhardt W, Mülling N, Behrendt S, Benson S, Dolff S, Führer D, Tan S
2021. Endocrine. Aug;73(2):367-373. doi: 10.1007/s12020-021-02640-1
Perinatal exposure to the thyroperoxidase inhibitors methimazole and amitrole perturbs thyroid hormone system signaling and alters motor activity in rat offspring.
Ramhøj L, Svingen T, Frädrich C, Rijntjes E, Wirth EK, Pedersen K, Köhrle J, Axelstad M
2022. Toxicol Lett 354:44-55. doi: 10.1016/j.toxlet.2021.10.010
Natural Autoimmunity to Selenoprotein P Impairs Selenium Transport in Hashimoto's Thyroiditis.
Sun Q, Mehl S, Renko K, Seemann P, Görlich CL, Hackler J, Minich WB, Kahaly GJ, Schomburg L
2021. Int J Mol Sci 22(23):13088. doi: 10.3390/ijms222313088
The Nutritional Supply of Iodine and Selenium Affects Thyroid Hormone Axis Related Endpoints in Mice.
Lossow K, Renko K, Schwarz M, Schomburg L, Schwerdtle T, Kipp AP
2021. Nutrients 13(11):3773. doi: 10.3390/nu13113773
Copper Isotopes and Copper to Zinc Ratio as Possible Biomarkers for Thyroid Cancer.
Kazi Tani LS, Gourlan AT, Dennouni-Medjati N, Telouk P, Dali-Sahi M, Harek Y, Sun Q, Hackler J, Belhadj M, Schomburg L, Charlet L
2021. Front Med (Lausanne) 8:698167. doi: 10.3389/fmed.2021.698167
Selenium Deficiency Due to Diet, Pregnancy, Severe Illness, or COVID-19-A Preventable Trigger for Autoimmune Disease.
Schomburg L
2021. Int J Mol Sci 22(16):8532. doi: 10.3390/ijms22168532
Age-dependent response to T4 overtreatment and recovery on systemic and organ level.
Kerp H, Renko K, Hönes GS, Brix K, Köhrle J, Moeller LC, Führer D
2021. J Mol Endocrinol 67(4):161-172. doi: 10.1530/JME-21-0109
Thyroid hormone system disrupting chemicals.
Köhrle J, Frädrich C
2021. Best Pract Res Clin Endocrinol Metab 35(5):101562. doi: 10.1016/j.beem.2021.101562
Testing for heterotopia formation in rats after developmental exposure to selected in vitro inhibitors of thyroperoxidase.
Ramhøj L, Frädrich C, Svingen T, Scholze M, Wirth EK, Rijntjes E, Köhrle J, Kortenkamp A, Axelstad M
2021. Environ Pollut 283:117135. doi: 10.1016/j.envpol.2021.117135
Design and Characterization of a Fluorescent Reporter Enabling Live-cell Monitoring of MCT8 Expression.
Graffunder AS, Paisdzior S, Opitz R, Renko K, Kühnen P, Biebermann H
2021. Exp Clin Endocrinol Diabetes. doi: 10.1055/a-1522-8535
Caloric restriction disrupts the microbiota and colonization resistance.
Jumpertz von Schwartzenberg R, Bisanz E, Lyalina S, Spanogiannopoulos P, Ang Q, Cai J, Dickmann S, Friedrich M, Liu S, Collins S, Ingebrigsten D, Miller S, Turnbaugh J, Patterson A, Pollard K, Mai K, Spranger J, Turnbaugh P
2021. Nature. doi: 10.1038/s41586-021-03663-4
Protective effects of thyroid hormone deprivation on progression of maladaptive cardiac hypertrophy and heart failure.
Kerp H, Hönes GS, Tostik E, Hönes-Wendland J, Gassen J, Moeller LC, Lorenz K, Führer D
2021. Frontiers in Cardiovascular Medicine. 8:683522 doi: 10.10.3389/fcvm2021.683522
Thyroid wars: the rise of central actions.
Capelli V, Diéguez C, Mittag J, López M
2021. Trends Endocrinol Metab 32(9):659-671 doi: 10.1016/2021.05.006
Maternal thyroid hormone programs cardiovascular functions in the offspring.
Pedaran M, Oelkrug R, Sun Q, Resch J, Schomburg L, Mittag J
2021. Thyroid. doi: 10.1089/thy.2021.0275
A New Mechanism in THRA Resistance: The First Disease-Associated Variant Leading to an Increased Inhibitory Function of THRA2.
Paisdzior S, Knierim E, Kleinau G, Biebermann H, Krude H, Straussberg R, Schuelke M
2021. Int J Mol Sci 22(10):5338. doi: 10.3390/ijms22105338
Thyroid Hormone Deficiency Modifies Hepatic Lipid Droplet Morphology and Molecular Properties in Lithogenic-Diet Supplemented Mice.
Kube I, Jastrow H, Führer D, Zwanziger D
2021. Exp Clin Endocrinol Diabetes, 129(12):926-930. doi: 10.1055/a-1404-7939
Relation of Serum Copper Status to Survival in COVID-19.
Hackler J, Heller RA, Sun Q, Schwarzer M, Diegmann J, Bachmann M, Moghaddam A, Schomburg L
2021. Nutrients, doi: 10.3390/nu13061898
Predicting neurological recovery after traumatic spinal cord injury by time-resolved analysis of monocyte subsets.
Heller RA, Seelig J, Crowell HL, Pilz M, Haubruck P, Sun Q, Schomburg L, Daniel V, Moghaddam A, Biglari B
2021. Brain, 144(10):3159-3174 doi: 10.1093/brain/awab203
Natural Autoimmunity to the Thyroid Hormone Monocarboxylate Transporters MCT8 and MCT10.
Porst T, Johannes J, Gluschke H, Köhler R, Mehl S, Kühnen P, Renko K, Minich WB, Wiegand S, Schomburg L
2021. Biomedicines, 9(5):496, doi: 10.3390/biomedicines9050496
Serum Selenium Status as a Diagnostic Marker for the Prognosis of Liver Transplantation.
Gül-Klein S, Haxhiraj D, Seelig J, Kästner A, Hackler J, Sun Q, Heller RA, Lachmann N, Pratschke J, Schmelzle M, Schomburg L
2021. Nutrients, doi: 10.3390/nu13020619
Noncanonical Thyroid Hormone Receptor α Action Mediates Arterial Vasodilation.
Geist D, Hönes GS, Gassen J, Kerp H, Kleinbongard P, Heusch G, Führer D, Moeller LC
2021. Endocrinology, 162(7):bqab099 doi: org/10.1210/endocr/bqab099
Oligodendrocyte progenitor cell maturation is dependent on dual function of MCT8 in the transport of thyroid hormone across brain barriers and the plasma membrane.
Vatine GD, Shelest O, Barriga BK, Ofan R, Rabinski T, Mattis VB, Heuer H, Svendsen CN
2021. Glia, 69(9):2146-2159 doi: org/10.1002/glia.24014
Comparative analysis of the effects of long-term 3,5-T2 treatment on the murine hepatic proteome and transcriptome under conditions of normal diet and high-fat diet.
Lietzow J, Golchert J, Pietzner M, Völker U, Poutanen M, Ohlsson C, Homuth G, Köhrle J
2021. Thyroid, 31(7):11135-1146 doi: 10.1089/thy.2020.0160
Hypothyroidism increases cholesterol gallstone prevalence in mice by elevated hydrophobicity of primary bile acids.
Kube I, Tardio LB, Hofmann U, Ghallab A, Hengstler JG, Führer D, Zwanziger D
2021. Thyroid, 31(6):973-984 doi: 10.1089/thy.2020.0636
Brain gene expression in systemic hypothyroidism and mouse models of MCT8 deficiency: the Mct8-Oatp1c1-Dio2 triad.
Morte B, Gil-Ibanez P, Heuer H, Bernal J
2021. Thyroid, 31(6):337-353, doi: 10.1089/thy.2020.0649
The circadian clock and metabolic homeostasis: entangled networks.
de Assis LVM, Oster H
2021. Cell Mol Life Sci. 2021 May;78(10):4563-4587. doi: 10.1007/s00018-021-03800-2
Increased Prevalence of Subclinical Hypothyroidism and Thyroid Autoimmunity in Depressed Adolescents: Results From a Clinical Cross-Sectional Study in Comparison to the General Pediatric Population.
Hirtz R, Föcker M, Libuda L, Antel J, Öztürk D, Kiewert C, Munteanu M, Peters T, Führer D, Zwanziger D, Thamm M, Hebebrand J, Grasemann C
2021. J Clin Psychiatry. Feb 23;82(2):20m13511. doi: 10.4088/JCP.20m13511
Evidence Based Use of LT4/LT3 Combinations in Treating Hypothyroidism: A Consensus Document.
Jonklaas J, Bianco AC, Cappola AR, Celi F, Fliers E, Heuer H, McAninch EA, Moeller LC, Nygaard B, Sawka AM, Watt T, Dayan CM
2021. Thyroid, 31(2):156-182, doi: 10.1089/thy.2020.0720
Absence of Both Thyroid Hormone Transporters MCT8 and OATP1C1 Impairs Neural Stem Cell Fate in the Adult Mouse Subventricular Zone.
Luongo C, Butruille L, Sebillot A, Le Blay K, Schwaninger M, Heuer H, Demeneix BA, Remaud S
2021. Stem Cell Reports, 16(2): 337-353, doi: 10.1016/j.stemcr.2020.12.009
Serum Selenium Status as a Diagnostic Marker for the Prognosis of Liver Transplantation.
Gül-Klein S, Haxhiraj D, Seelig J, Kästner A, Hackler J, Sun Q, Heller RA, Lachmann N, Pratschke J, Schmelzle M, Schomburg L
2021. Nutrients. Feb 14;13(2):619. doi: 10.3390/nu13020619
Selenium in Endocrinology-Selenoprotein-Related Diseases, Population Studies, and Epidemiological Evidence.
Köhrle J
2021. Endocrinology. Feb 1;162(2):bqaa228. doi: 10.1210/endocr/bqaa228
Establishing an Adult Mouse Brain Hippocampal Organotypic Slice Culture System that Allows for Tracing and Pharmacological Manipulation of ex vivo Neurogenesis.
Mayerl S, Ffrench-Constant C
2021. Bio Protoc. Jan 5;11(1):e3869. doi: 10.21769/BioProtoc.3869
Neurological Manifestations of COVID-19 Feature T Cell Exhaustion and Dedifferentiated Monocytes in Cerebrospinal Fluid.
Heming M, Li X, Räuber S, Mausberg AK, Börsch AL, Hartlehnert M, Singhal A, Lu IN, Fleischer M, Szepanowski F, Witzke O, Brenner T, Dittmer U, Yosef N, Kleinschnitz C, Wiendl H, Stettner M, Meyer Zu Hörste G
2021. Immunity. Jan 12;54(1):164-175.e6. doi: 10.1016/j.immuni.2020.12.011
Thyroid hormones in the regulation of brown adipose tissue thermogenesis.
Sentis SC, Oelkrug R, Mittag J
2021. Endocr Connect, 20(2):R106-R115, doi: org/10.1530/EC-20-0562
2020
Spatiotemporal Changes of Cerebral Monocarboxylate Transporter 8 Expression.
Wilpert NM, Krueger M, Opitz R, Sebinger D, Paisdzior S, Mages B, Schulz A, Spranger J, Wirth EK, Stachelscheid H, Mergenthaler P, Vajkoczy P, Krude H, Kühnen P, Bechmann I, Biebermann H
2020. Thyroid. Sep;30(9):1366-1383. doi: 10.1089/thy.2019.0544
Central Hypothyroidism Impairs Heart Rate Stability and Prevents Thyroid Hormone-Induced Cardiac Hypertrophy and Pyrexia.
Herrmann B, Harder L, Oelkrug R, Chen J, Gachkar S, Nock S, Resch J, Korkowski M, Heuer H, Mittag J
2020. Thyroid. Aug;30(8):1205-1216. doi: 10.1089/thy.2019.0705
Earlier Publications
Tanycytes control the hormonal output of the hypothalamic-pituitary-thyroid axis.
Müller-Fielitz H, Stahr M, Bernau M, Richter M, Abele S, Krajka V, Benzin A, Wenzel J, Kalies K, Mittag J, Heuer H, Offermanns S, Schwaninger M
2017. Nat Commun. Sep 7;8(1):484. doi: 10.1038/s41467-017-00604-6
Noncanonical thyroid hormone signaling mediates cardiometabolic effects in vivo.
Hönes GS, Rakov H, Logan J, Liao XH, Werbenko E, Pollard AS, Præstholm SM, Siersbæk MS, Rijntjes E, Gassen J, Latteyer S, Engels K, Strucksberg KH, Kleinbongard P, Zwanziger D, Rozman J, Gailus-Durner V, Fuchs H, Hrabe de Angelis M, Klein-Hitpass L, Köhrle J, Armstrong DL, Grøntved L, Bassett JHD, Williams GR, Refetoff S, Führer D, Moeller LC
2017. Proc Natl Acad Sci U S A. Dec 26;114(52):E11323-E11332. doi: 10.1073/pnas.1706801115
Transporters MCT8 and OATP1C1 maintain murine brain thyroid hormone homeostasis.
Mayerl S, Müller J, Bauer R, Richert S, Kassmann CM, Darras VM, Buder K, Boelen A, Visser TJ, Heuer H
2014. J Clin Invest. May;124(5):1987-99. doi: 10.1172/JCI70324
Thyroid hormone is required for hypothalamic neurons regulating cardiovascular functions.
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Inappropriate heat dissipation ignites brown fat thermogenesis in mice with a mutant thyroid hormone receptor α1.
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Abnormal thyroid hormone metabolism in mice lacking the monocarboxylate transporter 8.
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