2023
Hepatic Energy Metabolism under the Local Control of the Thyroid Hormone System.
Seifert J, Chen Y, Schöning W, Mai K, Tacke F, Spranger J, Köhrle J, Wirth EK.
2023. Int. J. Mol. Sci. 24(5):4861. doi: 10.3390/ijms24054861
Triac Treatment Prevents Neurodevelopmental and Locomotor Impairments in Thyroid Hormone Transporter Mct8/Oatp1c1 Deficient Mice.
Chen J, Salveridou E, Liebmann L, Sundaram SM, Doycheva D, Markova B, Hübner CA, Boelen A, Visser WE, Heuer H, Mayerl S.
2023. Int. J. Mol. Sci. 24(4):3452. doi: 10.3390/ijms24043452
Selenium, Iodine and Iron–Essential Trace Elements for Thyroid Hormone Synthesis and Metabolism.
Köhrle J.
2023. Int. J. Mol. Sci. 24(4):3393. doi: 10.3390/ijms24043393
Evolution of non-thyroidal illness syndrome in acute decompensation of liver cirrhosis and acute-on-chronic liver failure.
Langer M-M, Bauschen A, Guckenbiehl S, Klauss S, Lutz T, Denk G, Zwanziger D, Moeller LC and Lange CM.
2023. Front Endocrinol. 14:1104388. doi: 10.3389/fendo.2023.1104388
Single-cell RNA-based phenotyping reveals a pivotal role of thyroid hormone receptor alpha for hypothalamic development.
Sreenivasan VKA, Dore R, Resch J, Maier J, Dietrich C, Henck J, Balachandran S, Mittag J, Spielmann M.
2023. Development. 150 (3): dev201228. doi: 10.1242/dev.201228
The role of the circadian clock in the development, progression, and treatment of non-alcoholic fatty liver disease.
de Assis LVM, Demir M, Oster H.
2023. Acta Physiol (Oxf). 4:e13915. doi: 10.1111/apha.13915
2022
Thyroid hormones as a disease modifier and therapeutic target in nonalcoholic steatohepatitis.
Wirth EK, Puengel T, Spranger J, Tacke F.
2022. Expert Rev Endocrinol Metab. 17(5):425-434. doi: 10.1080/17446651.2022.2110864
Deiodinases control local cellular and systemic thyroid hormone availability
Köhrle J, Frädrich C.
2022. Free Radic Biol Med. 193(Pt 1):59-79. doi: 10.1016/j.freeradbiomed.2022.09.024
Cell-Specific Transport and Thyroid Hormone Receptor Isoform Selectivity Account for Hepatocyte-Targeted Thyromimetic Action of MGL-3196
Hönes GS, Sivakumar RG, Hoppe C, König J, Führer D, Moeller LC.
2022. Int J Mol Sci. 23(22):13714. doi: 10.3390/ijms232213714
Validation of Mct8/Oatp1c1 dKO mice as a model organism for the Allan-Herndon-Dudley Syndrome
Maity-Kumar G, Ständer L, DeAngelis M, Lee S, Molenaar A, Becker L, Garrett L, Amerie OV, Hoelter SM, Wurst W, Fuchs H, Feuchtinger A, Gailus-Durner V, Garcia-Caceres C, Othman AE, Brockmann C, Schöffling VI, Beiser K, Krude H, Mroz PA, Hofmann S, Tuckermann J, DiMarchi RD, Hrabe de Angelis M, Tschöp MH, Pfluger PT, Müller TD.
2022. Mol Metab. 66:101616. doi: 10.1016/j.molmet.2022.101616
Cardioprotection by Hypothyroidism Is Not Mediated by Favorable Hemodynamics-Role of Canonical Thyroid Hormone Receptor Alpha Signaling
Pape J, Kerp H, Lieder HR, Geist D, Hönes GS; Moeller LC, Kleinbongard P, Führer D.
2022. Int J Mol Sci. 23(21):13340. doi: 10.3390/ijms232113340
TRIAC Treatment Improves Impaired Brain Network Function and White Matter Loss in Thyroid Hormone Transporter Mct8/Oatp1c1 Deficient Mice
Reinwald JR, Weber-Fahr W, Cosa-Linan A, Becker R, Sack M, Falfan-Melgoza C, Gass N, Braun U, Clemm von Hohenberg C, Chen J, Mayerl S, Muente TF, Heuer H*, Sartorius A*. *equal contribution
2022. Int J Mol Sci. 23(24):15547. doi: 10.3390/ijms232415547
3,5-T2-an Endogenous Thyroid Hormone Metabolite as Promising Lead Substance in Anti-Steatotic Drug Development?
Sane R, Wirth EK, Köhrle J.
2022. Metabolites.12(7):582. doi: 10.3390/metabo12070582
Hepatobiliary Thyroid Hormone Deficiency Impacts Bile Acid Hydrophilicity and Aquaporins in Cholestatic C57BL/6J Mice
Kube I, Kowalczyk M, Hofmann U, Ghallab A, Hengstler JG, Führer D, Zwanziger D.
2022. Int. J. Mol. Sci. 23(20), 12355. doi: 10.3390/ijms232012355
Development and validation of an LC-MS/MS methodology for the quantification of thyroid hormones in dko MCT8/OATP1C1 mouse brain
Angelis MD, Maity-Kumar G, Schriever SC, Kozlova EV, Müller TD, Pfluger PT, Curras-Collazo MC, Schramm KW.
2022. J Pharm Biomed Anal 10;221:115038. doi: 10.1016/j.jpba.2022.115038
Gene therapy targeting the blood-brain barrier improves neurological symptoms in a model of genetic MCT8 deficiency
Sundaram SM, Arrulo Pereira A, Müller-Fielitz H, Köpke H, De Angelis M, Müller TD, Heuer H, Körbelin J, Krohn M, Mittag J, Nogueiras R, Prevot V, Schwaninger M.
2022. Brain 5;awac243. doi: 10.1093/brain/awac243
Rewiring of liver diurnal transcriptome rhythms by triiodothyronine (T3) supplementation
de Assis L, Harder L, Lacerda JT, Parsons R, Kaehler M, Cascorbi I, Nagel I, Rawashdeh O, Mittag J, Oster H.
2022. Elife 27;11:e79405 doi: 10.7554/eLife.79405
TRα2-An Untuned Second Fiddle or Fine-Tuning Thyroid Hormone Action?
Hönes S, Härting N, Mittag J, Kaiser F.
2022. Int J Mol Sci 23(13):6998. doi: 10.3390/ijms23136998
Too much too soon – Tissue-specific inactivation of deiodinase type 3 prematurely exposes brown fat to thyroid hormone.
Oelkrug R, Mittag J.
2022. Endocrinology bqac032. doi: org/10.1210/endocr/bqac032
The interplay of thyroid hormones and the immune system – where we stand and why we need to know about it.
Wenzek C, Boelen A, Westendorf AM, Engel DR, Möller LC, Führer D.
2022. Eur J Endocrinol EJE-21-1171. doi: 10.1530/EJE-21-1171
Distinct actions of the thyroid hormone transporters Mct8 and Oatp1c1 in murine mouse adult hippocampal neurogenesis.
Mayerl S, Alcaide Martin A, Bauer R, Schwaninger M, Heuer H*, ffrench-Constant C*. *equal contribution
2022. Cells 11(3):524. doi: 10.3390/cells11030524
Canonical thyroid hormone receptor β action stimulates hepatocyte proliferation in male mice.
Hönes GS, Kerp H, Hoppe C, Kowalczyk M, Zwanziger D, Baba HA, Führer D, Moeller LC.
2022. Endocrinology bqac003. doi: org/10.1210/endocr/bqac003
Thyroid hormone transporter deficiency in mice impacts multiple stages of GABAergic interneuron development.
Mayerl S, Chen J, Salveridou E, Boelen A, Darras VM, Heuer H.
2022. Cerebral Cortex. 32(2):329-341. doi: 10.1093/cercor/bhab211
2021
Perinatal exposure to the thyroperoxidase inhibitors methimazole and amitrole perturbs thyroid hormone system signaling and alters motor activity in rat offspring.
Ramhøj L, Svingen T, Frädrich C, Rijntjes E, Wirth EK, Pedersen K, Köhrle J, Axelstad M.
2022. Toxicol Lett 354:44-55. doi: 10.1016/j.toxlet.2021.10.010
Natural Autoimmunity to Selenoprotein P Impairs Selenium Transport in Hashimoto's Thyroiditis.
Sun Q, Mehl S, Renko K, Seemann P, Görlich CL, Hackler J, Minich WB, Kahaly GJ, Schomburg L.
2021. Int J Mol Sci 22(23):13088. doi: 10.3390/ijms222313088
The Nutritional Supply of Iodine and Selenium Affects Thyroid Hormone Axis Related Endpoints in Mice.
Lossow K, Renko K, Schwarz M, Schomburg L, Schwerdtle T, Kipp AP.
2021. Nutrients 13(11):3773. doi: 10.3390/nu13113773
Copper Isotopes and Copper to Zinc Ratio as Possible Biomarkers for Thyroid Cancer.
Kazi Tani LS, Gourlan AT, Dennouni-Medjati N, Telouk P, Dali-Sahi M, Harek Y, Sun Q, Hackler J, Belhadj M, Schomburg L, Charlet L.
2021. Front Med (Lausanne) 8:698167. doi: 10.3389/fmed.2021.698167
Selenium Deficiency Due to Diet, Pregnancy, Severe Illness, or COVID-19-A Preventable Trigger for Autoimmune Disease.
Schomburg L.
2021. Int J Mol Sci 22(16):8532. doi: 10.3390/ijms22168532
Age-dependent response to T4 overtreatment and recovery on systemic and organ level.
Kerp H, Renko K, Hönes GS, Brix K, Köhrle J, Moeller LC, Führer D.
2021. J Mol Endocrinol 67(4):161-172. doi: 10.1530/JME-21-0109
Thyroid hormone system disrupting chemicals.
Köhrle J, Frädrich C.
2021. Best Pract Res Clin Endocrinol Metab 35(5):101562. doi: 10.1016/j.beem.2021.101562
Testing for heterotopia formation in rats after developmental exposure to selected in vitro inhibitors of thyroperoxidase.
Ramhøj L, Frädrich C, Svingen T, Scholze M, Wirth EK, Rijntjes E, Köhrle J, Kortenkamp A, Axelstad M.
2021. Environ Pollut 283:117135. doi: 10.1016/j.envpol.2021.117135
Design and Characterization of a Fluorescent Reporter Enabling Live-cell Monitoring of MCT8 Expression.
Graffunder AS, Paisdzior S, Opitz R, Renko K, Kühnen P, Biebermann H.
2021. Exp Clin Endocrinol Diabetes. doi: 10.1055/a-1522-8535
Caloric restriction disrupts the microbiota and colonization resistance.
Jumpertz von Schwartzenberg R, Bisanz E, Lyalina S, Spanogiannopoulos P, Ang Q, Cai J, Dickmann S, Friedrich M, Liu S, Collins S, Ingebrigsten D, Miller S, Turnbaugh J, Patterson A, Pollard K, Mai K, Spranger J, Turnbaugh P.
2021. Nature. doi: 10.1038/s41586-021-03663-4
Protective effects of thyroid hormone deprivation on progression of maladaptive cardiac hypertrophy and heart failure.
Kerp H, Hönes GS, Tostik E, Hönes-Wendland J, Gassen J, Moeller LC, Lorenz K, Führer D.
2021. Frontiers in Cardiovascular Medicine. 8:683522 doi: 10.10.3389/fcvm2021.683522
Thyroid wars: the rise of central actions.
Capelli V, Diéguez C, Mittag J, López M.
2021. Trends Endocrinol Metab 32(9):659-671 doi: 10.1016/2021.05.006
Maternal thyroid hormone programs cardiovascular functions in the offspring.
Pedaran M, Oelkrug R, Sun Q, Resch J, Schomburg L, Mittag J.
2021. Thyroid. doi: 10.1089/thy.2021.0275
A New Mechanism in THRA Resistance: The First Disease-Associated Variant Leading to an Increased Inhibitory Function of THRA2.
Paisdzior S, Knierim E, Kleinau G, Biebermann H, Krude H, Straussberg R, Schuelke M.
2021. Int J Mol Sci 22(10):5338. doi: 10.3390/ijms22105338
Thyroid Hormone Deficiency Modifies Hepatic Lipid Droplet Morphology and Molecular Properties in Lithogenic-Diet Supplemented Mice.
Kube I, Jastrow H, Führer D, Zwanziger D.
2021. Exp Clin Endocrinol Diabetes, 129(12):926-930. doi: 10.1055/a-1404-7939
Relation of Serum Copper Status to Survival in COVID-19.
Hackler J, Heller RA, Sun Q, Schwarzer M, Diegmann J, Bachmann M, Moghaddam A, Schomburg L.
2021. Nutrients, doi: 10.3390/nu13061898
Predicting neurological recovery after traumatic spinal cord injury by time-resolved analysis of monocyte subsets.
Heller RA, Seelig J, Crowell HL, Pilz M, Haubruck P, Sun Q, Schomburg L, Daniel V, Moghaddam A, Biglari B.
2021. Brain, 144(10):3159-3174 doi: 10.1093/brain/awab203
Natural Autoimmunity to the Thyroid Hormone Monocarboxylate Transporters MCT8 and MCT10.
Porst T, Johannes J, Gluschke H, Köhler R, Mehl S, Kühnen P, Renko K, Minich WB, Wiegand S, Schomburg L.
2021. Biomedicines, 9(5):496, doi: 10.3390/biomedicines9050496
Serum Selenium Status as a Diagnostic Marker for the Prognosis of Liver Transplantation.
Gül-Klein S, Haxhiraj D, Seelig J, Kästner A, Hackler J, Sun Q, Heller RA, Lachmann N, Pratschke J, Schmelzle M, Schomburg L.
2021. Nutrients, doi: 10.3390/nu13020619
Noncanonical Thyroid Hormone Receptor α Action Mediates Arterial Vasodilation.
Geist D, Hönes GS, Gassen J, Kerp H, Kleinbongard P, Heusch G, Führer D, Moeller LC.
2021. Endocrinology, 162(7):bqab099 doi: org/10.1210/endocr/bqab099
Oligodendrocyte progenitor cell maturation is dependent on dual function of MCT8 in the transport of thyroid hormone across brain barriers and the plasma membrane.
Vatine GD, Shelest O, Barriga BK, Ofan R, Rabinski T, Mattis VB, Heuer H, Svendsen CN.
2021. Glia, 69(9):2146-2159 doi: org/10.1002/glia.24014
Comparative analysis of the effects of long-term 3,5-T2 treatment on the murine hepatic proteome and transcriptome under conditions of normal diet and high-fat diet.
Lietzow J, Golchert J, Pietzner M, Völker U, Poutanen M, Ohlsson C, Homuth G, Köhrle J.
2021. Thyroid, 31(7):11135-1146 doi: 10.1089/thy.2020.0160
Hypothyroidism increases cholesterol gallstone prevalence in mice by elevated hydrophobicity of primary bile acids.
Kube I, Tardio LB, Hofmann U, Ghallab A, Hengstler JG, Führer D, Zwanziger D.
2021. Thyroid, 31(6):973-984 doi: 10.1089/thy.2020.0636
Brain gene expression in systemic hypothyroidism and mouse models of MCT8 deficiency: the Mct8-Oatp1c1-Dio2 triad.
Morte B, Gil-Ibanez P, Heuer H, Bernal J.
2021. Thyroid, 31(6):337-353, doi: 10.1089/thy.2020.0649
Evidence Based Use of LT4/LT3 Combinations in Treating Hypothyroidism: A Consensus Document.
Jonklaas J, Bianco AC, Cappola AR, Celi F, Fliers E, Heuer H, McAninch EA, Moeller LC, Nygaard B, Sawka AM, Watt T, Dayan CM.
2021. Thyroid, 31(2):156-182, doi: 10.1089/thy.2020.0720
Absence of Both Thyroid Hormone Transporters MCT8 and OATP1C1 Impairs Neural Stem Cell Fate in the Adult Mouse Subventricular Zone.
Luongo C, Butruille L, Sebillot A, Le Blay K, Schwaninger M, Heuer H, Demeneix BA, Remaud S.
2021. Stem Cell Reports, 16(2): 337-353, doi: 10.1016/j.stemcr.2020.12.009
Thyroid hormones in the regulation of brown adipose tissue thermogenesis.
Sentis SC, Oelkrug R, Mittag J.
2021. Endocr Connect, 20(2):R106-R115, doi: org/10.1530/EC-20-0562
