Impact of TH on tanycyte functions and the relevance on central regulation of the liver and hormone uptake
Dr. Helge Müller-Fielitz
Tanycytes are important gatekeepers to transport TH into the CNS. Tanycytes themselves react to TH, which could modulate essential functions of tanycytes, such as their morphology or the transport of hormones. This project will focus on the role of TH in tanycytic functions and will clarify their effects on tanycytic morphology and hormonal transport into the cerebrospinal fluid. Additionally, this project will clarify the importance of local tanycytic distribution of TH into the VMH, which has an influence on liver metabolism.
Project Team Members
| Name | Position | Phone | |
|---|---|---|---|
| Dr. Akila Chandrasekar | Postdoc | +49 451 3101 7220 | |
| Andreea Constantinescu | PhD candidate | +49 451 3101 7232 | |
| Vanessa Neve | PhD candidate | +49 451 3101 7215 | |
| Sebastian Abele | MD candidate | +49 451 3101 7232 | |
| Frauke Spiecker | Lab Technician | +49 451 3101 7244 |
Further Information
Selected Publications
Tanycytes control the hormonal output of the hypothalamic-pituitary-thyroid axis.
Müller-Fielitz H, Stahr M, Bernau M, Richter M, Abele S, Krajka V, Benzin A, Wenzel J, Kalies K, Mittag J, Heuer H, Offermanns S, Schwaninger M.
2017. Nature Comm 8: 481. doi: 10.1038/s41467-017-00604-6
The Role of Tanycytes in the Hypothalamus-Pituitary-Thyroid Axis and the Possibilities for Their Genetic Manipulation.
Müller-Fielitz H, Schwaninger M.
2020. Exp Clin Endocrinol Diabetes 128(6-07):388-394. doi: 10.1055/a-1065-1855
Maternal thyroid hormone is required for parvalbumin neurone development in the anterior hypothalamic area.
Harder L, Dudazy-Gralla S, Müller-Fielitz H, Hjerling Leffler J, Vennström B, Heuer H, Mittag J.
2018. J Neuroendocrinol 30(3):e12573. doi: 10.1111/jne.12573
The LepR-mediated leptin transport across brain barriers controls food reward.
Di Spiezio A, Sandin ES, Dore R, Müller-Fielitz H, Storck SE, Bernau M, Mier W, Oster H, Jöhren O, Pietrzik CU, Lehnert H, Schwaninger M.
2018. Mol Metab 8:13-22. doi: 10.1016/j.molmet.2017.12.001
NF-κB signaling in tanycytes mediates inflammation-induced anorexia.
Böttcher M, Müller-Fielitz H, Sundaram SM, Gallet S, Neve V, Shionoya K, Zager A, Quan N, Liu X, Schmidt-Ullrich R, Haenold R, Wenzel J, Blomqvist A, Engblom D, Prevot V, Schwaninger M.
2020. Mol Metab 39:101022. doi: 10.1016/j.molmet.2020.101022
