A brain imaging approach to TH function in consequence to mutations in TH receptors and transporter proteins
PD Dr. med. Anna Cirkel (née Göbel) & Prof. Dr. med. Thomas F. Münte
TH action is critical for the human brain. TH action is mediated by a number of molecules, e.g. TH transporters and receptors (THT, TR). We aim to demonstrate that genetic variations in THTs and TRs contribute to the neuropsychological phenotype and, by using multimodal brain imaging and electrophysiology, will identify the underlying systems-level neural mechanisms.
Project Team Members
| Name | Position | Phone | |
|---|---|---|---|
| PD Dr. rer. nat. Marcus Heldmann | PD | +49 451 3101 7442 | |
| Dr. Anna Antufjew | Postdoc | ||
| Dr. rer. nat. Martin Göttlich | Postdoc | +49 451 3101 7427 | |
| Dr. Jan Christoph Uter | Postdoc | ||
| Dr. Tobias Wagner-Altendorf | Postdoc |
Further Information
Selected Publications
Performance monitoring and behavioral adaptation during task switching: an fMRI study.
von der Gablentz J, Tempelmann C, Münte TF, Heldmann M.
2015. Neuroscience 285:227-35. doi: 10.1016/j.neuroscience.2014.11.024
Plasma proteome and metabolome characterization of an experimental human thyrotoxicosis model.
Pietzner M, Engelmann B, Kacprowski T, Golchert J, Dirk A-L, Hammer E, Iwen KA, Nauck M, Wallaschofski H, Führer D, Münte TF, Friedrich UV, Homuth G, Brabant G.
2017. BMC Med 15(1):6. doi: 10.1186/s12916-016-0770-8
Machine Learning Based Classification of Resting-State fMRI Features Exemplified by Metabolic State (Hunger/Satiety).
Al-Zubaidi A, Mertins A, Heldmann M, Jauch-Chara K, Münte TF.
2019. Front Hum Neurosci 13:164. doi: 10.3389/fnhum.2019.00164
Experimentally induced thyrotoxicosis leads to increased connectivity in temporal lobe structures: a resting state fMRI study.
Göttlich M, Heldmann M, Göbel A, Dirk AL, Brabant G, Münte TF.
2015. Psychoneuroendocrinology 56:100-9. doi: 10.1016/j.psyneuen.2015.03.009
Single Nucleotide Polymorphisms in Thyroid Hormone Transporter Genes MCT8, MCT10 and Deiodinase DIO2 contribute to inter-individueal variance of executive functions and personality traits.
Uter JC, Krämer UM, Schöls L, Rodriguez-Fornells A, Göbel A, Heldmann M, Lichtner P, Brabant G, Münte TF.
2019. Exp Clin Endocrinol Diabetes 128(9):573-581. doi: 10.1055/a-1065-1786
Effect of Mild Thyrotoxicosis on Performance and Brain Activations in a Working Memory Task.
Göbel A, Heldmann M, Göttlich M, Dirk AL, Brabant G, Münte TF.
2016. PLoS One 11(8): e0161552. doi: 10.1371/journal.pone.0161552
Mild Thyrotoxicosis Leads to Brain Perfusion Changes: An Arterial Spin Labelling Study.
Göbel A, Heldmann M, Sartorius A, Göttlich M, Dirk AL, Brabant G, Münte TF.
2017. J Neuroendocrinol 29(1). doi: 10.1111/jne.12446
Partial withdrawal of levothyroxine treated disease leads to brain activations and effects on performance in a working memory task: A pilot study.
Göbel A, Heldmann M, Göttlich M, Georges R, Nieberding R, Sartorius A, Brabant G, Münte TF.
2019. J Neuroendocrin 31(4):e12707. doi: 10.1111/jne.12707
Experimentally induced subclinical hypothyroidism causes decreased functional connectivity of the cuneus: A resting state fMRI study.
Göbel A, Göttlich M, Heldmann M, Georges R, Nieberding R, Rogge B, Sartorius A, Brabant G, Münte TF.
2018. Psychoneuroendocrinology 102:158-163. doi: 10.1016/j.psyneuen.2018.12.012
The Influence of Thyroid Hormones on Brain Structure and Function in Humans.
Göbel A, Göttlich M, Reinwald J, Rogge B, Uter JC, Heldmann M, Sartorius A, Brabant G, Münte TF.
2020. Exp Clin Endocrinol Diabetes 128(6-07):432-436. doi: 10.1055/a-1101-9090
