TH transporters in myelin formation and regeneration

Prof. Dr. Heike Heuer &  Prof. Dr. Daniel R. Engel

 TH regulates myelination in developing and mature CNS. Here, we aim to unravel the cell-intrinsic functions of the TH transporters Mct8 and Oatp1c1 during oligodendrocyte differentiation by studying developmental myelination and myelin repair in cell-specific Mct8/Oatp1c1-deficient mice. We will also test whether novel TH analogues can drive proper myelination in Mct8/Oatp1c1 DKO mice and may thus be considered as treatment option for patients with MCT8 deficiency (Allan-Herndon-Dudley Syndrome).



Project Team Members

Dr. rer. nat. Steffen Mayerl Junior Group Leader (Team Heuer), associated +49 201 723 82227 This email address is being protected from spambots. You need JavaScript enabled to view it.
Dr. rer. nat Boyka Markova Postdoc  (Team Heuer) +49 201 723 5677 This email address is being protected from spambots. You need JavaScript enabled to view it.
Markus Korkowski Lab Technician (Team Heuer) +49 201 723 82511 Mail
Philippa Spangenberg PhD candidate (Team Engel)  +49 201 723 6073 This email address is being protected from spambots. You need JavaScript enabled to view it.
Jenny Dick Lab Technician (Team Engel) +49 201 723 6072 This email address is being protected from spambots. You need JavaScript enabled to view it.

Further Information

Homepage Team Heuer

Homepage Team Engel

Selected Publications

Thyroid hormone transporters.
Groeneweg S, van Geest FS, Peeters RP, Heuer H, Visser WE. 
2020. Endocrine Reviews 41(2). doi: 10.1210/endrev/bnz008

Hippocampal neurogenesis requires cell-autonomous thyroid hormone signaling.
Mayerl SHeuer H, Ffrench-Constant C.
2020. Stem Cell Reports 14: 845-860. doi: 10.1016/j.stemcr.2020.03.014

Thyroid hormone transporters Mct8 and Oatp1c1 control skeletal muscle regeneration.
Mayerl S, Schmidt M, Doycheva D, Darras VM, Hüttner SS, Boelen A, Visser TJ, Kaether C, Heuer H*, von Maltzahn J*. *equal contribution.
2018. Stem Cell Reports 10: 1959-1974; doi: 10.1016/j.stemcr.2018.03.021

Transporters MCT8 and OATP1C1 maintain murine brain thyroid hormone homeostasis.
Mayerl S, Müller J, Bauer R, Richert S, Kassmann CM, Darras VM, Buder K, Boelen A, Visser TJ, and Heuer H.
2014. J Clin Invest. 124: 1987-1999. doi: 10.1172/JCI70324

In vitro and mouse studies support therapeutic utility of triiodothyroacetic acid in MCT8 deficiency.
Kersseboom S, Horn S, Visser WE, Chen J, Friesema ECH, Vaurs-Barrière C, Peeters RP, Heuer H*, Visser TJ*. *equal contribution.
2014. Molecular Endocrinology  28: 1961-1970. doi: 10.1210/me.2014-1135

Spatial proteomics revealed a CX3CL1-dependent crosstalk between the urothelium and relocated macrophages through IL-6 during an acute bacterial infection in the urinary bladder.
Bottek J, Soun C, Lill JK, Dixit A, Thiebes S, Beerlage AL, Horstmann M, Urbanek A, Heuer H, Uszkoreit J, Eisenacher M, Bracht T, Sitek B, Hoffmann F, Vijitha N, von Eggeling F, Engel DR.
2020. Mucosal Immunol 13(4):702-714. doi: 10.1038/s41385-020-0269-7

Irf4-dependent CD103(+)CD11b(+) dendritic cells and the intestinal microbiome regulate monocyte and macrophage activation and intestinal peristalsis in postoperative ileus.
Pohl JM, Gutweiler S, Thiebes S, Volke JK, Klein-Hitpass L, Zwanziger D, Gunzer M, Jung S, Agace WW, Kurts D, Engel DR.
2017. Gut 66(12):2110-2120. doi: 10.1136/gutjnl-2017-313856

CX3CR1 Reduces Kidney Fibrosis by Inhibiting Local Proliferation of Profibrotic Macrophages.
Engel DR, Krause TA, Snelgrove SL, Thiebes S, Hickey MJ, Boor P, Kitching AR, Kurts C.
2015. J Immunol 194:1628-1638, doi:10.4049/jimmunol.1402149

Crosstalk between Sentinel and Helper Macrophages Permits Neutrophil Migration into Infected Uroepithelium.
Schiwon M, Weisheit C, Franken L, Gutweiler S, Dixit A, Meyer-Schwesinger C, Pohl JM, Maurice NJ, Thiebes S, Lorenz K, Quast T, Fuhrmann M, Baumgarten G, Lohse MJ, Opdenakker G, Bernhagen J, Bucala R, Panzer U, Kolanus W, Gröne HJ, Garbi N, Kastenmüller W, Knolle PA, Kurts C, Engel DR.
2014. Cell 156(3):456-68. doi: 10.1016/j.cell.2014.01.006

T helper type 1 memory cells disseminate postoperative ileus over the entire intestinal tract.
Engel DR, Koscielny A, Wehner S, Maurer J, Schiwon M, Franken L, Schumak B, Limmer A, Sparwasser T, Hirner A, Knolle PA, Kalff JC, Kurts C.
2010. Nat Med 16(12):1407-13. doi: 10.1038/nm.2255