TH receptor α1 at the crossroad of autonomic and cardiac functions in mice
Prof. Dr. Jens Mittag
TH is of great importance for cardiac rhythmicity, as tachycardia is often observed in hyperthyroidism, while bradycardia is a leading symptom in hypothyroid patients. It is commonly assumed that the regulation of heart rate by TH is predominantly an effect of TH within the heart; however, recent studies showed that also central TH actions contribute to this phenotype. In the proposed project we now aim to dissect the local from the central actions of TH in the control of heart rate with a focus on the predominant receptor in heart and brain, TRα1.
Project Team Members
| Name | Position | Phone | |
|---|---|---|---|
| Dr. rer. nat. Riccardo Dore | Postdoc | +49 451 3101 7821 | |
| Beke Kolms | PhD candidate | +49 451-31017832 | |
| Julia Maier | PhD candidate | +49 451 3101 7822 |
Further Information
Selected Publications
Maternal thyroid hormone programs cardiovascular functions in the offspring.
Pedaran M, Oelkrug R, Sun Q, Resch J, Schomburg L, Mittag J.
2021. Thyroid. doi: 10.1089/thy.2021.0275
Maternal Thyroid Hormone is Required for Parvalbumin Neuron Development in the Anterior Hypothalamic Area.
Harder L, Dudazy-Gralla S, Müller-Fielitz H, Hjerling Leffler J, Vennström B, Heuer H, Mittag J.
2018. J Neuroendocrinol 30(3):e12573. doi: 10.1111/jne.12573
Thermoregulatory and Cardiovascular Consequences of a Transient Thyrotoxicosis and Recovery in Male Mice.
Hoefig CS, Harder L, Oelkrug R, Meusel M, Vennström B, Brabant G, Mittag J.
2016. Endocrinology 157(7):2957-67. doi: 10.1210/en.2016-1095
Inappropriate heat dissipation ignites brown fat thermogenesis in mice with a mutant thyroid hormone receptor α1.
Warner A, Rahman A, Solsjö P, Gottschling K, Davis B, Vennström B, Arner A, Mittag J.
2013. Proc Natl Acad Sci U S A 110(40):16241-16246. doi: 10.1073/pnas.1310300110
Thyroid hormone is required for hypothalamic neurons regulating cardiovascular functions.
Mittag J, Lyons DJ, Sällström J, Vujovic M, Dudazy-Gralla S, Warner A, Wallis K, Alkemade A, Nordström K, Monyer H, Broberger C, Arner A, Vennström B.
2013. J Clin Invest 2;123(1):509-516. doi: 10.1172/JCI65252
Thyroid Hormone Induced Browning of White Adipose Tissue Does Not Contribute to Thermogenesis and Glucose Consumption.
Johann K, Cremer AL, Fischer AW, Heine M, Pensado ER, Resch J, Nock S, Virtue S, Harder L, Oelkrug R, Astiz M, Brabant G, Warner A, Vidal-Puig A, Oster H, Boelen A, Lopez M, Heeren J, Dalley JW, Backes H, Mittag J.
2019. Cell Rep 27(11):3385-3400. doi: 10.1016/j.celrep.2019.05.054
