TH receptor-clock interaction in NAFLD development
Prof. Dr. Henrik Oster
Circadian clocks regulate organ responses to external stimuli such as TH through tissue-specific transcriptional programmes. In the liver, many TH target genes show robust circadian regulation, demonstrating temporal modulation of local TH action – despite largely constant tissue T3 levels. We will analyse clock-TRβ interaction in the regulation of hepatic lipid metabolism in mice with genetic disruption of liver clock or TR signalling and test this interaction as a potential TRβ-targeted (chrono-)therapy for fatty liver disease.
Project Team Members
| Name | Position | Phone | |
|---|---|---|---|
| Dr. Leonardo de Assis | Postdoc |
Further Information
Selected Publications
The circadian phase of antenatal glucocorticoid treatment affects the risk of behavioral disorders.
Astiz M, Heyde I, Fortmann MI, Bossung V, Roll C, Stein A, Grüttner B, Göpel W, Härtel C, Obleser J, Oster H.
2020. Nat Commun 11(1):3593. doi: 10.1038/s41467-020-17429-5
An adipokine feedback regulating diurnal food intake rhythms in mice.
Tsang AH, Koch CE, Kiehn JT, Schmidt CX, Oster H.
2020. Elife 9:e55388. doi: 10.7554/eLife.55388
Circadian regulation of hedonic appetite in mice by clocks in dopaminergic neurons of the VTA.
Koch CE, Begemann K, Kiehn JT, Griewahn L, Mauer J, M E Hess, Moser A, Schmid SM, Brüning JC, Oster H.
2020. Nat Commun 11(1):3071. doi: 10.1038/s41467-020-16882-6
Circadian clock network desynchrony promotes weight gain and alters glucose homeostasis in mice.
Kolbe I, Leinweber B, Brandenburger M, Oster H.
2019. Mol Metab 30:140-151. doi: 10.1016/j.molmet.2019.09.012
Thyroid Hormone Induced Browning of White Adipose Tissue Does Not Contribute to Thermogenesis and Glucose Consumption.
Johann K, Cremer AL, Fischer AW, Heine M, Pensado ER, Resch J, Nock S, Virtue S, Harder L, Oelkrug R, Astiz M, Brabant G, Warner A, Vidal-Puig A, Oster H, Boelen A, Lopez M, Heeren J, Dalley JW, Backes H, Mittag J.
2019. Cell Rep 27(11):3385-3400. doi: 10.1016/j.celrep.2019.05.054
