Liver-specific TH activity in NAFLD and NASH
Prof. Dr. med. Joachim Spranger, Prof. Dr. med. Frank Tacke & Dr. Eva K. Wirth
We aim to define the effects of local TH availability in the development and progression of non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH). Deiodinases are key enzymes involved in the local activation and inactivation of TH. We will analyse the effect of genetic deletion and siRNA-based knockdown of deiodinases in appropriate rodent models, and study the modulation of genes implicated in local TH availability in human liver samples with different degrees of liver pathology.
Project Team Members
| Name | Position | Phone | |
|---|---|---|---|
| Dr. rer. nat. Alix Bruneau | Postdoc (Team Tacke) | ||
| Dr. Isabella Lurje | Postdoc (Team Tacke) | ||
| Dr. med. Laura Schmidt-Pennington | Postdoc (Team Tacke Wirth) | ||
| Yingfu Chen | PhD candidate (Team Tacke, Wirth) | ||
| Wiebke Werner | MD candidate (Team Tacke) |
Further Information
Selected Publications
Roles of CCR2 and CCR5 for Hepatic Macrophage Polarization in Mice With Liver Parenchymal Cell-Specific NEMO Deletion.
Bartneck M, Koppe C, Fech V, Warzecha KT, Kohlhepp M, Huss S, Weiskirchen R, Trautwein C, Luedde T, Tacke F.
2021. Cell Mol Gastroenterol Hepatol 2021;11(2):327-347. doi: 10.1016/j.jcmgh.2020.08.012
Controversies and Opportunities in the Use of Inflammatory Markers for Diagnosis or Risk Prediction in Fatty Liver Disease.
Lambrecht J, Tacke F.
2021. Front Immunol 11:634409. doi: 10.3389/fimmu.2020.634409
In Situ Vaccination as a Strategy to Modulate the Immune Microenvironment of Hepatocellular Carcinoma.
Lurje I, Werner W, Mohr R, Roderburg C, Tacke F, Hammerich L.
2021. Front Immunol 12:650486. doi: 10.3389/fimmu.2021.650486
An Unexpected Line of Defense: Hepatoprotective Eosinophils in Ischemia-Reperfusion Injury.
Peiseler M, Tacke F.
2021. Hepatology May 11. doi: 10.1002/hep.31895. Epub ahead of print
Inflammatory Mechanisms Underlying Nonalcoholic Steatohepatitis and the Transition to Hepatocellular Carcinoma.
Peiseler M, Tacke F.
2021. Cancers (Basel) 13(4):730. doi: 10.3390/cancers13040730
Deciphering the Immune Microenvironment on A Single Archival Formalin-Fixed Paraffin-Embedded Tissue Section by An Immediately Implementable Multiplex Fluorescence Immunostaining Protocol.
Guillot A, Kohlhepp MS, Bruneau A, Heymann F, Tacke F.
2020. Cancers (Basel) 12(9):2449. doi: 10.3390/cancers12092449
Dendritic Cell and T Cell Crosstalk in Liver Fibrogenesis and Hepatocarcinogenesis: Implications for Prevention and Therapy of Liver Cancer.
Lurje I, Hammerich L, Tacke F.
2020. Int J Mol Sci 21(19):7378. doi: 10.3390/ijms21197378
Editorial: prevalence, progression rates and mortality predictors of non-alcoholic fatty liver disease reflected by German statutory health insurance data.
Puengel T, Tacke F.
2020. Aliment Pharmacol Ther 52(8):1412-1413. doi: 10.1111/apt.16077
