Liver-specific TH activity in NAFLD and NASH

Prof. Dr. med. Joachim Spranger,  Prof. Dr. med. Frank Tacke  &  Dr. Eva K. Wirth

We aim to define the effects of local TH availability in the development and progression of non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH). Deiodinases are key enzymes involved in the local activation and inactivation of TH. We will analyse the effect of genetic deletion and siRNA-based knockdown of deiodinases in appropriate rodent models, and study the modulation of genes implicated in local TH availability in human liver samples with different degrees of liver pathology.

alcaide 

Project Team Members

NamePositionPhoneEmail
Dr. rer. nat. Alix Bruneau Postdoc (Team Tacke)   Mail
Dr. Isabella Lurje Postdoc (Team Tacke)   This email address is being protected from spambots. You need JavaScript enabled to view it.
Dr. med. Laura Schmidt-Pennington Postdoc (Team Tacke Wirth)   This email address is being protected from spambots. You need JavaScript enabled to view it.
Yingfu Chen PhD candidate (Team Tacke, Wirth)   This email address is being protected from spambots. You need JavaScript enabled to view it.
Wiebke Werner MD candidate (Team Tacke)   This email address is being protected from spambots. You need JavaScript enabled to view it.

Further Information

Homepage Team Spranger

Homepage Team Tacke

Homepage Team Wirth

Selected Publications

Roles of CCR2 and CCR5 for Hepatic Macrophage Polarization in Mice With Liver Parenchymal Cell-Specific NEMO Deletion.
Bartneck M, Koppe C, Fech V, Warzecha KT, Kohlhepp M, Huss S, Weiskirchen R, Trautwein C, Luedde T, Tacke F.
2021. Cell Mol Gastroenterol Hepatol 2021;11(2):327-347. doi: 10.1016/j.jcmgh.2020.08.012

Controversies and Opportunities in the Use of Inflammatory Markers for Diagnosis or Risk Prediction in Fatty Liver Disease.
Lambrecht J, Tacke F
2021. Front Immunol 11:634409. doi: 10.3389/fimmu.2020.634409

In Situ Vaccination as a Strategy to Modulate the Immune Microenvironment of Hepatocellular Carcinoma.
Lurje IWerner W, Mohr R, Roderburg C, Tacke F, Hammerich L. 
2021. Front Immunol 12:650486. doi: 10.3389/fimmu.2021.650486

An Unexpected Line of Defense: Hepatoprotective Eosinophils in Ischemia-Reperfusion Injury.
Peiseler M, Tacke F
2021. Hepatology May 11. doi: 10.1002/hep.31895. Epub ahead of print

Inflammatory Mechanisms Underlying Nonalcoholic Steatohepatitis and the Transition to Hepatocellular Carcinoma.
Peiseler M, Tacke F
2021. Cancers (Basel) 13(4):730. doi: 10.3390/cancers13040730

Deciphering the Immune Microenvironment on A Single Archival Formalin-Fixed Paraffin-Embedded Tissue Section by An Immediately Implementable Multiplex Fluorescence Immunostaining Protocol.
Guillot A, Kohlhepp MS, Bruneau A, Heymann F, Tacke F
2020. Cancers (Basel) 12(9):2449. doi: 10.3390/cancers12092449

Dendritic Cell and T Cell Crosstalk in Liver Fibrogenesis and Hepatocarcinogenesis: Implications for Prevention and Therapy of Liver Cancer.
Lurje I, Hammerich L, Tacke F
2020. Int J Mol Sci 21(19):7378. doi: 10.3390/ijms21197378

Editorial: prevalence, progression rates and mortality predictors of non-alcoholic fatty liver disease reflected by German statutory health insurance data.
Puengel T, Tacke F.  
2020. Aliment Pharmacol Ther 52(8):1412-1413. doi: 10.1111/apt.16077