Hepatic TH signalling in acute and acute-on-chronic liver injury
Prof. Dr. med. Lars C. Möller, Prof. Dr. med. Christian M. Lange & PD Dr. Denise Zwanziger
We hypothesise that TH improves hepatocyte survival and proliferation, steatosis, and inflammation in acute and acute-on-chronic liver failure (ALF and ACLF). Precise characterisation of local TH action will be performed in patient samples and distinct animal models of ALF and ACLF in which cell death and regeneration versus sterile and infection-complicated inflammation are predominant, in order to define targeted, cell-type and TR isoform-specific therapeutic opportunities in these scenarios.
Project Team Members
| Name | Position | Phone | |
|---|---|---|---|
| Dr. rer. nat. Sebastian Hönes | Postdoc (Team Möller) | +49 201 723 84646 | |
| Christoph Hoppe | PhD candidate (Team Möller) | +49 201 723 84646 | |
| Jakob Gloge | MD candidate (Team Möller) | +49 201 723 82215 | |
| Andrea Jäger | Lab Technician (Team Möller) | +49 201 723 83433 | |
| Dr. phil. nat. Sabrina Guckenbiehl | Postdoc (Team Lange) | +49 201 723 6032 | |
| Dr. rer. nat. Mona May Langer | Postdoc (Team Lange) | +49 89 4400-73175 | |
| Helena Stadler | PhD candidate (Team Lange) | +49 89 4400-73176 | |
| Dr. rer. nat. Manuela Kowalczyk | Postdoc (Team Zwanziger) | +49 201 723 83082 | |
| Elena Maria Schmaler | MD candidate (Team Zwanziger) | ||
| Kathrin Strumann | Lab Technician (Team Zwanziger) | +49 201 723 5085 | |
| Ann-Kathrin Schörding | Clinician Scientist (Team Möller) | +49 201 723 83845 |
Further Information
Selected Publications
Canonical thyroid hormone receptor β action stimulates hepatocyte proliferation in male mice.
Hönes GS, Kerp H, Hoppe C, Kowalczyk M, Zwanziger D, Baba HA, Führer D, Moeller LC.
2022. Endocrinology bqac003. doi: org/10.1210/endocr/bqac003
Noncanonical Action of Thyroid Hormone Receptors α and β.
Hönes GS, Geist D, Moeller LC.
2020. Exp Clin Endocrinol Diabetes 128(6-07):383-387. doi: 10.1055/a-1088-1187
Increased Anaplastic Lymphoma Kinase Activity Induces a Poorly Differentiated Thyroid Carcinoma in Mice.
Kohler H, Latteyer S, Hönes GS, Theurer S, Liao XH, Christoph S, Zwanziger D, Schulte JH, Kero J, Undeutsch H, Refetoff S, Schmid KW, Führer D, Moeller LC.
2019. Thyroid 29(10):1438-1446. doi: 10.1089/thy.2018.0526
Thyroxine promotes lung cancer growth in an orthotopic mouse model.
Latteyer S, Christoph S, Theurer S, Hönes GS, Schmid KW, Führer D, Moeller LC.
2019. Endocr Relat Cancer 26(6):565-574. doi: 10.1530/ERC-18-0353
Noncanonical thyroid hormone signaling mediates cardiometabolic effects in vivo.
Hönes GS, Rakov H, Logan J, Liao XH, Werbenko E, Pollard AS, Præstholm SM, Siersbæk MS, Rijntjes E, Gassen J, Latteyer S, Engels K, Strucksberg KH, Kleinbongard P, Zwanziger D, Rozman J, Gailus-Durner V, Fuchs H, Hrabě de Angelis M, Klein-Hitpass L, Köhrle J, Armstrong DL, Grøntved L, Bassett JHD, Williams GR, Refetoff S, Führer D, Moeller LC.
2017. Proc Natl Acad Sci U S A 26;114(52):E11323-E11332. doi: 10.1073/pnas.1706801115
A 6-Base Pair in Frame Germline Deletion in Exon 7 Of RET Leads to Increased RET Phosphorylation, ERK Activation, and MEN2A.
Latteyer S, Klein-Hitpass L, Khandanpour C, Zwanziger D, Poeppel TD, Schmid KW, Führer D, Moeller LC.
2016. J Clin Endocrinol Metab 101(3):1016-22. doi: 10.1210/jc.2015-2948
Vitamin D receptor and Jak-STAT signaling crosstalk results in calcitriol-mediated increase of hepatocellular response to IFN-α.
Lange CM, Gouttenoire J, Duong F, Morikawa K, Heim MH, Moradpour D.
2014. J Immunol 192(12):6037-44. doi: 10.4049/jimmunol.1302296
Macrophage-derived extracellular vesicles induce long-lasting immunity against hepatitis C virus which is blunted by polyunsaturated fatty acids.
Cai C, Koch B, Morikawa K, Suda G, Sakamoto N, Rüschenbaum S, Akhras S, Dietz J, Hildt E, Zeuzem S, Welsch C, Lange CM.
2018. Front Immunol 9:723. doi: 10.3389/fimmu.2018.00723
Influenza virus infection as precipitating event of acute-on-chronic liver failure.
Schutte A, Ciesek S, Wedemeyer H, Lange CM.
2019. J Hepatol 70(4):797-799. doi: 10.1016/j.jhep.2018.11.015
IL-22 and IL-22-Binding Protein Are Associated With Development of and Mortality From Acute-on-Chronic Liver Failure.
Schwarzkopf K, Rüschenbaum S, Barat S, Cai C, Mücke MM, Fitting D, Weigert A, Brüne B, Zeuzem S, Welsch C, Lange CM.
2019. Hepatol Commun 3:392-405. doi: 10.1002/hep4.1303
Quinolone- and multidrug-resistance predict failure of antibiotic prophylaxis of spontaneous bacterial peritonitis.
Mücke MM, Mayer A, Kessel J, Mücke VT, Bon D, Schwarzkopf K, Rüschenbaum S, Queck A, Göttig S, Vermehren A, Weiler N, Welker MW, Reinheimer C, Hogardt M, Vermehren J, Herrmann E, Kempf VAJ, Zeuzem S, Lange CM.
2020. Clin Infect Dis 70(9):1916-1924. doi: 10.1093/cid/ciz540
Differential regulation of monocarboxylate transporter 8 expression in thyroid cancer and hyperthyroidism.
Badziong J, Ting S, Tiedje V, Brix K, Brabant G, Möller LC, Schmid KW, Führer D, Zwanziger D.
2017. Eur J Endocrinol 177(3):243-250. doi: 10.1530/EJE-17-0279
The long N-terminus of the human monocarboxylate transporter 8 is a target of ubiquitin-dependent proteasomal degradation which regulates protein expression and oligomerization capacity.
Zwanziger D*, Schmidt M*, Fischer J, Kleinau G, Braun D, Schweizer U, Möller LC, Biebermann H, Führer D. *equal contribution
2017. Mol Cell Endocrinol 434:278-87. doi: 10.1016/j.mce.2016.05.017
Sex-dependent claudin-1 expression in the liver of euthyroid and hypothyroid mice.
Zwanziger D, Rakov H, Engels K, Möller LC, Führer D.
2015. Eur Thyroid J 4(suppl1):67-73. doi: 10.1159/000431316
The impact of claudin-1 on follicular thyroid carcinoma aggressiveness.
Zwanziger D*, Badziong J*, Ting S, Möller LC, Schmid KW, Siebolts U, Wickenhauser C, Dralle H, Führer D. *equal contribution
2015. Endocr Relat Cancer 22(5):819-30. doi: 10.1530/ERC-14-0502
