Collaborative Research Centre / Transregio 296

Local Control of Thyroid Hormone Action (LOCOTACT)

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Published: 02 September 2021

43rd annual ETA eConference 2021 - Programme

Only a few days are left until the opening of the European THYROID Association eConference 2021!
 
It is our great pleasure to announce six speakers of the LOCOTACT consortium:
 
Dr. Robert Opitz, Charité – Universitätsmedizin Berlin - Saturday (04.09.) Oral Session I: 01:00 PM - 02:45 PM
Dr. Steffen Mayerl, Universitätsklinikum Essen - Sunday (05.09.) Oral Session II: 06:15 PM – 07:15 PM
Prof. Jens Mittag, Universität zu Lübeck - Monday (06.09.) Scientific Symposium 6: 02:00 PM - 03:00 PM
Ann-Kathrin Schörding, Universitätsklinikum Essen - Tuesday (07.09.) Young Investigator Session: 02:00 PM – 03:00 PM
Dr. Janina Pape (née Gassen), Universitätsklinikum Essen - Tuesday (07.09.) Young Investigator Session: 02:00 PM – 03:00 PM
Dr. Sebastian Hönes, Universitätsklinikum Essen - Tuesday (07.09.) Oral Session 4: 04:15 PM – 05:15 PM
 
You can view the full programme here or download it here.
Published: 15 July 2021

The Physiological Society’s Annual Conference 2021: Presentation by Heike Heuer

Heike Heuer was invited to the 2021 Annual Conference of the Physiological Society - this year taking place as a virtual conference. On 14.07.2021 she gave her presentation entitled "Thyroid Transporters within the hypothalamus-pituitary thyroid axis".

LOCOTACT says thank you for representing your projects on this international stage.

Published: 01 July 2021

Four MD Fellowships within our iRTG

We warmly welcome four young scientists in LOCOTACT who successfully applied for iRTG MD Fellowships!
 
Audrey Bresser will investigate TH regulation of neuronal development in human cerebral organoids (Project 04; PI: Prof. Peter Kühnen).
Livia Hoerner will study selenium-contanining proteins as biomarkers of tissue function and damage (Project 17; PI: Prof. Lutz Schomburg).
Jonas Rotter will analyse the function and expression of thyroid hormone transporters in the elderly and in patients with neurodegenerative diseases (Project 03; PI: Prof. Ingo Bechmann).
Wiebke Werner will unravel the immune microenvironment of non-alcoholic fatty liver disease in the context of local thyroid hormone metabolism (Project 15; PI: Prof. Frank Tacke)
 
Good Luck with your projects!
Published: 04 June 2021

New LOCOTACT Project

We are pleased that the project of Dr. Steffen Mayerl on "Impact of thyroid hormone transport on seizure generation" is now part of LOCOTACT as Project 19. 
 
In this project, Dr. Mayerl and his team will investigate the pathogenic mechanisms underlying the increased seizure susceptibility of human MCT8 patients.
 
To this end, they will address the importance of TH transporters for different neuronal populations as well as the consequences of seizure induction in TH transporter deficiency and their role in the transition to epilepsy.
Published: 03 June 2021

LOCOTACT Online-Retreat

The 1st LOCOTACT annual retreat was a great success with thrilling talks and discussions in Zoom and Gather.Town. 
Four outstanding poster presentations by our young scientists were honoured with awards: 
  • Anna Molenaar (Project 05)
  • Daniel Ullrich (Project 08)
  • Nuria López Alcántara (Project 14)
  • Rajas Sane and Joshua Seifert (Project 16)
Published: 06 May 2021

Heike Heuer invited to Institute of Clinical Neuroscience and Medical Psychology, University Düsseldorf

Yesterday, LOCOTACT PI Heike Heuer visited our neighbour University Hospital in Düsseldorf. At the seminar of the Institute of Clinical Neuroscience and Medical Psychology she talked about the "Role of thyroid hormone transporters in brain development and function".

Published: 29 January 2021

Karl-Oberdisse-Preis für M.Sc. Irina Kube

M.Sc. Irina Kube (Essen) erhielt auf der 26. Jahrestagung der Nordrhein-Westfälischen Gesellschaft für Endokrinologie & Diabetologie den Karl-Oberdisse-Preis für ihre Studien zur Gallensteinentstehung unter Hypothyreose - Wir gratulieren herzlich!

Published: 17 December 2020

Schilddrüse – das unterschätzte Organ

Die einen sind ständig müde, unkonzentriert und frieren leicht, die anderen klagen über Herzrasen, Schlaflosigkeit und Hitzewallungen.
 
Hinter beidem steckt oftmals eine Erkrankung der Schilddrüse. Jeder dritte Deutsche leidet im Verlaufe seines Lebens an einer Schilddrüsenveränderung.
 
Das kleine Organ unterhalb des Kehlkopfes wird häufig unterschätzt. Dabei lenkt es viele wichtige Funktionen im Körper.
Zum Video
Published: 01 December 2020

Schilddrüse: Mehr Hirn durch Jod? Interview

Die nur 25 Gramm schwere Schilddrüse liegt wie ein Schmetterling an der Vorderseite des Halses - und sie ist eine richtige Hormonfabrik.
 
Sie beeinflusst Stoffwechsel und Wachstum, stärkt die Knochen und reguliert das seelische Wohlbefinden.
 
Und: Sie sie ist ein zentraler Faktor für die Leistungsfähigkeit unseres Gehirns.
Zum Interview

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Central Office

University of Duisburg-Essen
c/o University Hospital Essen
Department of Endocrinology, Diabetes and Metabolism
E-Mail: locotact@uk-essen.de

CRC/TR296

As a truly interdisciplinary research consortium LocoTact is well equipped to meet the challenge of defining local control of TH action and to develop translational strategies tailored to cells and tissues with the perspective to capitalise on the power of the hormone to treat rare or prevalent diseases.

Speaker at UDE

Prof. Dr. Dr. Dagmar Führer-Sakel
Dagmar.Fuehrer-Sakel@uk-essen.de

Co-Speaker at UzL

Prof. Dr. Jens Mittag
jens.mittag@uni-luebeck.de

Co-Speaker at Charité

Prof. Dr. Peter Kühnen
peter.kuehnen@charite.de

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