Collaborative Research Centre / Transregio 296

Local Control of Thyroid Hormone Action (LOCOTACT)

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Published: 18 April 2023

BMBF funds Advanced CS Programme UMEA2

The University Medicine Essen Clinician Scientist Academy (UMEA) and the Advanced Clinician Scientist (ACS) program UMEA2 stand for excellent research and clinical expertise in Essen.

The Advanced Clinician Scientist (ACS) program UMEA2 is designed to enable research-active physicians to combine clinical activity and research. The target group of the new program are medical specialists who have completed or will soon complete their habilitation and who are able to lead their own research group. UMEA2 is headed by Prof. Ulrike Bingel with LOCOACT Spokesperson Dagmar Führer-Sakel as co-applicant and funded by the German Federal Ministry of Education and Research (BMBF). 

For early career Clinician Scientists, the program UMEA offers the opportunity to obtain further scientific qualifications under optimal conditions parallel to their clinical work. In February 2022 UMEA has been approved for a further two years by the German Research Foundation (DFG) and has been in existence since 2019 under the direction of  LOCOTACT spokesperson Dagmar Führer-Sakel.

Find more information on UMEA and UMEA2 here.

 

 

Published: 14 April 2023

Steffen Mayerl invited to ErasmusMC Lecture Series on Endocrinology

The Lectures on Endocrinology organized by the department of Internal medicine at the Erasmus MC in Rotterdam are monthly meetings based on a wide spectrum of the endocrinology field. Invited (international) speakers are worldwide experts in their field with an outstanding list of scientific achievements. Lectures are both clinical as well as research based.

On 13.04.2023 LOCOTACT PI Steffen Mayerl was invited to this online seminar and talked about "Cell-specific roles of thyroid hormone transporters"

Published: 13 April 2023

Kristina Lorenz represents LOCOTACT at Annual Meeting of the German Cardiac Society

LOCOTACT was represented at the 89th Meeting of the German Cardiac Society (DGK).
Our PI Kristina Lorenz was invited to this year's DGK meeting in Mannheim. Her talk in the session "Endocrine-metabolic factors and cardiovascular diseases", held on April, 12th 2023, was entitled "Intracellular thyroid hormone sensitivity and their possible role for heart diseases?"

Published: 03 March 2023

Inspiring and motivating insights into diverse career options

The LOCOTACT Career Days were a successful event for all participants and guest speakers! We look back on two days of great insights into the many career opportunities available to our Clinician Scientists, PostDocs, and MDs and PhDs.

Many thanks go to: Dagmar Führer, Alexander Boreham, Kostja Renko, Timo Müller, Marius Richter, Christian Strasburger, Denise Zwanziger, Peter Kühnen, Corina Madreiter-Sokolowski, Roman Rehor, Vedrana Tabor, Niels-Peter Becker, Mariel Morales-Sahm, Thomas Wallach & Bettina Otto.

For more details, please have a look on our programme.

Published: 13 February 2023

LOCOTACT publication deciphers new role of thyroid hormones in early brain development!

In the study single-cell RNA sequencing technology was used to obtain an unbiased global view of the role of TRα1 in hypothalamus development, cell-type diversity and the cellular transcriptome. The groups of Prof. Malte Spielmann and Prof. Jens Mittag could show that defective TRα1 signaling has surprisingly little effect on the development of hypothalamic neuronal populations. In contrast, it heavily affects the development of hypothalamic oligodendrocytes, which seem to require TRα1 signaling for full maturation. They subsequently demonstrate that early postnatal thyroid hormone action is crucial for the development of this cell type. Read more. 
Find the publication here.

Published: 09 February 2023

Successful start of the Joint Online Event Series: Equity and Female Opportunities in Academia

On Wednesday, 08.02.2023 we started into our online event series with a workshop entitled: Are you hiring the best people? Limiting unconscious bias by structuring employee selection held by Prof. Dr. Tanja Hentschel, University of Amsterdam, Amsterdam Business School.

Tanja Hentschel explained why and how biases and stereotypes in the application process can influence personnel selection.
All participants got great insights how we can reduce these biases through professional personnel selection processes and how we can customize them.
Because in the end, we all want to hire the person who is best suited for the position and not the person who is most like us, don’t we?

Many thanks to Tanja Hentschel and all participants from TRR 289 Treatment Expectation and CRC/TR 296 LOCOTACT!

 

Please find the upcoming events in the Joint Online Event Series here.

Published: 31 October 2022

“Thyroxin – a Christmas Crystal” - Dagmar Führer at Birkenstein Hormone Conference

“Thyroxin – a Christmas Crystal” - this was the poetic title of the invited lecture given by LOCOTACT spokesperson and PI Dagmar Führer at the well-known "After-Dinner-Lecture" on 28th of October 2022 at the 34th Birkenstein Hormone Conference in Fischbachau, Germany. 

Since its foundation in 1987, the Birkenstein Hormone Conference has evolved as a well-known meeting and for many endocrinologists it became a yearly appointment  in the annual conference repertoire.

 

Published: 24 October 2022

ATA 2022: Heike Heuer gives invited talk

Heike Heuer was invited to this year's meeting of the American Thyroid Association (ATA) in Montréal, Quebec, Canada.

In the session "Novel Animal Models of Thyroid Disease" on 21.10.2022, she reported on "Novel mouse models of TH function in the brain". 

 

 

Lecture Astrid Westendorf
Published: 19 October 2022

LOCOTACT Lectures - Astrid Westendorf

On October, 27th, 2022, Prof. Astrid Westendorf, Institute of Immunology, University Hospital Essen, talked about
"Immune responses in the intestinal mucosa: Inflammation versus immunoregulation" in the first LOCOTACT lecture of the winter semester.
 
You can download there lecture poster here.
We thank all guests that joined the LOCOTACT lecture! 

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Central Office

University of Duisburg-Essen
c/o University Hospital Essen
Department of Endocrinology, Diabetes and Metabolism
E-Mail: locotact@uk-essen.de

CRC/TR296

As a truly interdisciplinary research consortium LocoTact is well equipped to meet the challenge of defining local control of TH action and to develop translational strategies tailored to cells and tissues with the perspective to capitalise on the power of the hormone to treat rare or prevalent diseases.

Speaker at UDE

Prof. Dr. Dr. Dagmar Führer-Sakel
Dagmar.Fuehrer-Sakel@uk-essen.de

Co-Speaker at UzL

Prof. Dr. Jens Mittag
jens.mittag@uni-luebeck.de

Co-Speaker at Charité

Prof. Dr. Peter Kühnen
peter.kuehnen@charite.de

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