Collaborative Research Centre / Transregio 296

Local Control of Thyroid Hormone Action (LOCOTACT)

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Published: 05 August 2022

New publication!

Congratulations to Adriana Arrulo Pereira (PhD candidate in P01), her PI Markus Schwaninger and all team members to this excellent publication doi: 10.1093/brain/awac243

It is Adriana's first shared 1st Authorship!

Well done!!!

Published: 24 June 2022

LOCOTACT Lectures - Tienush Rassaf

LOCOTACT thanks Professor Tienush Rassaf for presenting his research to our consortium.
 
Under the title "Cardioprotection in acute myocardial infarction - per aspera ad astra” all guests got an impression of the broad range of cardiovascular pathologies and mechanisms of cardiotoxicity. 
 
The lively discussion after the lecture rounded off a successful scientific evening.
Published: 20 June 2022

First LOCOTACT-RDM Workshop in Medical and Biomedical Sciences

Did you ever search for your own data and lose track of your documentation? Did you ever fail to reproduce someone elses research? Wouldn’t it be nice if your data would be well organized right from the beginning of a project?

This week, Stephanie Rehwald and Sophia Leimer (INF project, Research Data Services University Library Duisburg-Essen) as well as Birte Lindstädt and Justine Vandendorpe (ZB MED, Information Centre for Life Sciences) gave insights how good research data management can make the difference. In this interactive workshop, they shared practical tips and tricks how to manage and document data throughout data collection, analysis, publication, long-term storage, archiving, and how to prepare data for reuse.
 
Many thanks to the whole organizing team for this very important workshop for all LOCOTACT members!
Published: 14 June 2022

LOCOTACT Retreat 2022 - THANK YOU

We are delighted that 2022 offered the opportunity for all LOCOTACT members to finally meet in person for our 2nd annual LOCOTACT retreat and we wish to thank each and every one cordially again for the participation.
After all the covid-related limitations, it was highly motivating and refreshing to see so many LOCOTACT members in Münster.
Especially the scientific work conducted and presented by our younger LOCOTACT members left a lasting impression.
 
We want to congratulate you for the achievements and strongly encourage you to proceed with such enthusiasm in your Master, PhD, MD theses and PostDoc projects.
The poster sessions have been on a remarkable high scientific level and four outstanding presentations could be awarded with poster prizes.
Congratulations!

news locotact retreat thank you beitrag

Four outstanding poster presentations have been awarded with prizes! Awardees from left to right: Jonas Rotter (P03), Joshua Seifert (P16), Riccardo Dore (P12) and Nina Härting (P11).
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LOCOTACT is truly evolving in a scientific and personal manner. With enthusiasm we are looking forward for upcoming excellent scientific publications resulting from collaborations across the projects and research sites.
LOCOTACT projects will substantially contribute to the knowledge of rare and common diseases and we aim to apply novel technologies to push the boundaries.
 
We are convinced to be on the right track with our LOCOTACT projects and strongly encourage you to carry on full speed and with the positive spirit we experienced during the retreat.
 
THANK YOU!

Published: 20 May 2022

LOCOTACT Lectures - Anthony Martin Gerdes

Yesterday we enjoyed the LOCOTACT lecture given by Prof. Dr. Anthony Martin Gerdes from the Department of Biomedical Sciences at the New York College of Osteopathic Medicine, New York Institute of Technology.
Thank you very much for taking your time!
 
Professor Gerdes explained the consequences of low cardiac T3 and talked about recent clinical studies in the context of thyroid hormone treatment of heart failure.
Published: 29 April 2022

LOCOTACT Lectures - Anthony Hollenberg

Many thanks to our guest Prof. Dr. Anthony Hollenberg, for his inspiring talk in the context of our monthly LOCOTACT lectures.
 
We really appreciate the new insights into thyroid hormone action Prof. Hollenberg shared and, moreover, the time he invested in the detailed and vital discussion following his talk. 

Published: 07 April 2022

LOCOTACT Workshop Series - Equal Opportunities in Research

The CRC/TR 296 aims to improve chances for women’s careers in science by raising the awareness of their strengths and potentials. Therefore, we are pleased to announce the LOCOTACT Workshop Series 2022/2023: Equal Opportunities in Research.
 
The workshops address your motivation to develop own action plans, improve your communication and leaderships skills, or transport your knowledge using an effective and attractive scientific writing style.
All workshops take place online and combine lecture with active discussions, exercises, and peer workshopping.
You can download the Workshop poster here.
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We will gladly accept your registration or questions via e-mail to This email address is being protected from spambots. You need JavaScript enabled to view it.
Be quick – limited number of participants for each workshop!
Published: 29 March 2022

Four young scientists received LOCOTACT iRTG MD Fellowships 2022!

Like in 2021, the iRTG is happy to support four new MD candidates with fellowships! 
 
Tobias Bolte examines the role of thyroid hormone action in human cortical development (Project P04; PI: Prof. Peter Kühnen).
Jakob Gloge investigates thyroid hormone effects on ethanol-induced hepatocyte damage (Project P18; PI: Prof. Lars Möller).
Katharina Kotzur characterizes the potential of seletive deiodinase inhibitors in intact cells in vitro (Project P16; PI: Prof. Josef Köhrle).
Elena Schmaler studies the impact of a moderate thyroid hormone deficiency on cholestatic liver disease in male mice (Project P18; PI: PD Dr. Denise Zwanziger).
 
Welcome to LOCOTACT, good luck with your projects and congratulations to all of you!
Published: 22 March 2022

LOCOTACT at the 65th German Congress of Endocrinology (DGE) Annual Meeting

With its own symposium, LOCOTACT was present at this year’s annual meeting of the German Congress of Endocrinology (DGE). Originally planned to take place in Baden-Baden, Germany, the congress committee decided to go for another virtual event. 

On Saturday, 19.03.2022, the LOCOTACT symposium was chaired by Professor Dagmar Führer-Sakel (Essen) and Professor Jens Mittag (Lübeck). During the symposium, our CRC/TR 296 members Dr. Helge Müller-Fielitz, (Lübeck), Professor Lars Möller (Essen), and Professor Henrik Oster (Lübeck) gave insights in their scientific research. LOCOTACT members were present in various sessions of the congress; among them PIs Dr. Steffen Mayerl (P19), Professor Joachim Spranger (P15), and iRTG students Nuria López Alcántara (P14), and Julia Maier (P12).

Prior to opening of the DGE annual meeting, Professor Dagmar Führer-Sakel was invited to give a statement in the online press conference. In this context, she gave our consortium a stage and presented the topics and aims of LOCOTACT to the attending journalists. You can access a record of the press conference here: DGE Congress press conference
 
Following the press conference, Medical Tribune published a report about LOCOTACT:
Medical Tribune LOCOTACT
 
See you at the DGE congress in 2023!

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Upcoming Events

07
Jun
Save the Date - LOCOTACT Retreat 2023 and International Conference
Atlantic Congress Hotel
-
Essen

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Central Office

Administration

University of Duisburg-Essen
c/o University Hospital Essen
Department of Endocrinology, Diabetes and Metabolism
Phone: +49 201/723 - 5350
E-Mail: locotact@uk-essen.de

CRC/TR296

As a truly interdisciplinary research consortium LocoTact is well equipped to meet the challenge of defining local control of TH action and to develop translational strategies tailored to cells and tissues with the perspective to capitalise on the power of the hormone to treat rare or prevalent diseases.

Speaker at UDE

Prof. Dr. Dr. Dagmar Führer-Sakel
Dagmar.Fuehrer-Sakel@uk-essen.de

Co-Speaker at UzL

Prof. Dr. Jens Mittag
jens.mittag@uni-luebeck.de

Co-Speaker at Charité

Prof. Dr. Heiko Krude
heiko.krude@charite.de

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